Gagliardi Mariacristina, Mazzolai Barbara
Center for Micro Bio-Robotics @SSSA, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, 56025, Pontedera, Pisa, Italy.
Future Med Chem. 2015;7(2):123-38. doi: 10.4155/fmc.14.140.
Molecular imprinting (MI) represents a strategy to introduce a 'molecular memory' in a polymeric system obtaining materials with specific recognition properties. MI particles can be used as drug delivery systems providing a targeted release and thus reducing the side effects. The introduction of molecular recognition properties on a polymeric drug carrier represents a challenge in the development of targeted delivery systems to increase their efficiency. This review will summarize the limited number of drug delivery MI particles described in the literature along with an overview of potential solutions for a larger exploitation of MI particles as targeted drug delivery carriers. Molecularly imprinted drug carriers can be considered interesting candidates to significantly improve the efficiency of a controlled drug treatment.
分子印迹（MI）是一种在聚合物体系中引入“分子记忆”以获得具有特定识别特性材料的策略。MI颗粒可用作药物递送系统，实现靶向释放，从而减少副作用。在聚合物药物载体上引入分子识别特性是开发靶向递送系统以提高其效率的一项挑战。本综述将总结文献中描述的数量有限的药物递送MI颗粒，同时概述更广泛利用MI颗粒作为靶向药物递送载体的潜在解决方案。分子印迹药物载体可被视为显著提高药物控制治疗效率的有吸引力的候选者。
