Luliński Piotr
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warszawa, Poland.
Acta Pol Pharm. 2013 Jul-Aug;70(4):601-9.
In recent years, the investigations of new drug delivery systems have been directed on the development of some "intelligent" drug delivery devices that are able to directly respond to the patient's individual needs. New drug delivery systems should maximize the efficiency of administrated therapeutic agents and improve the patient's quality of life. Introduction of the new drug delivery devices is an important scientific goal, which could be achieved by combining new technologies and intelligent biomaterials. Molecular imprinting technology has a high potential for the preparation of optimized drug delivery forms. Here, molecularly imprinted polymers (MIPs) are promising new materials for such purposes, but their application in this field is nowadays at a developing stage. In this review, the principles of molecular imprinting and the recognition-release mechanisms of polymeric matrices are discussed. The potential application of molecularly imprinted materials as the future drug delivery systems with various administering routes (transdermal, ocular or oral) are presented, and some future prospects for the imprinted polymers are outlined.
近年来，对新型药物递送系统的研究主要集中在开发一些能够直接响应患者个体需求的“智能”药物递送装置上。新型药物递送系统应最大限度地提高给药治疗剂的效率，并改善患者的生活质量。引入新型药物递送装置是一个重要的科学目标，这可以通过结合新技术和智能生物材料来实现。分子印迹技术在制备优化的药物递送形式方面具有很大潜力。在此，分子印迹聚合物（MIPs）是用于此类目的的有前景的新材料，但其在该领域的应用目前尚处于发展阶段。在本综述中，讨论了分子印迹的原理以及聚合物基质的识别 - 释放机制。介绍了分子印迹材料作为具有各种给药途径（透皮、眼部或口服）的未来药物递送系统的潜在应用，并概述了印迹聚合物的一些未来前景。
