Kappen C, Schughart K, Ruddle F H
Department of Biology, Yale University, New Haven, CT 06511.
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5459-63. doi: 10.1073/pnas.86.14.5459.
Antennapedia-class vertebrate homeobox genes have been classified with regard to their chromosomal locations and nucleotide sequence similarities within the 183-base-pair homeobox domain. The results of these comparisons support the view that in mammals and most likely the vertebrates, four clusters of homeobox genes exist that were created by duplications of an entire primordial gene cluster. We present evidence that this primordial cluster arose by local gene duplications of homeoboxes that were present before the divergence of arthropods and chordates. Sequence analyses indicate that the expansion of the primordial gene cluster complex was accompanied by diversification, whereas conservation predominated after the duplications of entire homeobox gene clusters.
触角足类脊椎动物同源框基因已根据其在183个碱基对的同源框结构域内的染色体位置和核苷酸序列相似性进行了分类。这些比较结果支持这样一种观点，即在哺乳动物以及很可能在脊椎动物中，存在四个同源框基因簇，它们是由一个完整的原始基因簇复制而成的。我们提供的证据表明，这个原始基因簇是由节肢动物和脊索动物分化之前就已存在的同源框的局部基因复制产生的。序列分析表明，原始基因簇复合体的扩展伴随着多样化，而在整个同源框基因簇复制之后则以保守为主。
