Ingham P W
ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK.
Nature. 1988 Sep 1;335(6185):25-34. doi: 10.1038/335025a0.
Analysis of the genes that control the early events of Drosophila embryogenesis is providing details of the molecular processes underlying the positional specification of cells. There are two distinct phases: the first precedes the cellularization of the blastoderm embryo and is associated with a cascade of interactions between transcriptional regulators; the second occurs after cellularization and depends on communication between cells. These processes may be conserved in a wide range of invertebrates and vertebrates.
对控制果蝇胚胎发育早期事件的基因进行分析,正在揭示细胞位置特化背后分子过程的细节。有两个不同阶段:第一个阶段先于囊胚层胚胎的细胞化,并与转录调节因子之间的一系列相互作用相关;第二个阶段发生在细胞化之后,依赖于细胞间的通讯。这些过程可能在广泛的无脊椎动物和脊椎动物中是保守的。