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果蝇胚胎模式形成的分子遗传学

The molecular genetics of embryonic pattern formation in Drosophila.

作者信息

Ingham P W

机构信息

ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK.

出版信息

Nature. 1988 Sep 1;335(6185):25-34. doi: 10.1038/335025a0.

Abstract

Analysis of the genes that control the early events of Drosophila embryogenesis is providing details of the molecular processes underlying the positional specification of cells. There are two distinct phases: the first precedes the cellularization of the blastoderm embryo and is associated with a cascade of interactions between transcriptional regulators; the second occurs after cellularization and depends on communication between cells. These processes may be conserved in a wide range of invertebrates and vertebrates.

摘要

对控制果蝇胚胎发育早期事件的基因进行分析,正在揭示细胞位置特化背后分子过程的细节。有两个不同阶段:第一个阶段先于囊胚层胚胎的细胞化,并与转录调节因子之间的一系列相互作用相关;第二个阶段发生在细胞化之后,依赖于细胞间的通讯。这些过程可能在广泛的无脊椎动物和脊椎动物中是保守的。

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