Baumann A, Seefeld R, Werner I, Seifert B, Witte M, Pollex S, Grisk A
Institut für Pharmakologie und Toxikologie, Ernst-Moritz-Arndt-Universität Griefswald.
Pharmazie. 1989 Mar;44(3):215-8.
After oral administration of B 24/76 (1) on experimental animals (rat, minipig, dog) and human beings 11 metabolites could be isolated from urine, faeces and bile. The structure of 7 compounds was elucidated by means of TLC and MS. The investigated species are showing an analogues metabolic pattern with differences in the intensity and main metabolites. In phase II-reaction we could observe qualitative differences.
在对实验动物（大鼠、小型猪、狗）和人类口服B 24/76（1）后，可从尿液、粪便和胆汁中分离出11种代谢物。通过薄层色谱法（TLC）和质谱法（MS）阐明了7种化合物的结构。所研究的物种显示出类似的代谢模式，但在强度和主要代谢物方面存在差异。在第二阶段反应中，我们可以观察到定性差异。
