[大鼠、小型猪、犬和人体中B 24/76的生物转化]
[Biotransformation of B 24/76 in the rat, minipig, dog and man].
作者信息
Baumann A, Seefeld R, Werner I, Seifert B, Witte M, Pollex S, Grisk A
机构信息
Institut für Pharmakologie und Toxikologie, Ernst-Moritz-Arndt-Universität Griefswald.
出版信息
Pharmazie. 1989 Mar;44(3):215-8.
PMID:2568641
Abstract
After oral administration of B 24/76 (1) on experimental animals (rat, minipig, dog) and human beings 11 metabolites could be isolated from urine, faeces and bile. The structure of 7 compounds was elucidated by means of TLC and MS. The investigated species are showing an analogues metabolic pattern with differences in the intensity and main metabolites. In phase II-reaction we could observe qualitative differences.
摘要
在对实验动物（大鼠、小型猪、狗）和人类口服B 24/76（1）后，可从尿液、粪便和胆汁中分离出11种代谢物。通过薄层色谱法（TLC）和质谱法（MS）阐明了7种化合物的结构。所研究的物种显示出类似的代谢模式，但在强度和主要代谢物方面存在差异。在第二阶段反应中，我们可以观察到定性差异。
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