Mützel W, Langer M, Keysser R
Fortschr Geb Rontgenstrahlen Nuklearmed Erganzungsbd. 1989;128:101-4.
After injection of iopromide or iopamidol into a central vein in 40 patients ages 57 +/- 14 years and 57 +/- 11 years, respectively, with normal renal function, iodine concentration and total iodine excretion were determined in pooled urine over 0 to 2 hours and 2 to 24 hours after injection. Iopromide excretion of 46.4 +/- 9.8% of the dose during the first 2 hours after injection was significantly (p less than 0.05) higher than that of iopamidol, which amounted to 41.4 +/- 10.5% of the dose. This is presumably due to the fact that iopromide has lower protein binding than iopamidol. Excretion of the two nonionic contrast media up to 2 hours after injection decreased constantly with increasing age. In the case of iopromide, a mean excretion of 55% of the dose in a patient 25 years old decreased to about 40% for a patient 90 years of age (p less than 0.05). The clinical relevance of the observed differences and correlations is discussed.
分别对40名年龄为57±14岁和57±11岁、肾功能正常的患者经中心静脉注射碘普罗胺或碘帕醇后，在注射后0至2小时以及2至24小时收集的尿液中测定碘浓度和总碘排泄量。碘普罗胺在注射后最初2小时内的排泄量占剂量的46.4±9.8%，显著高于碘帕醇（p<0.05），碘帕醇的排泄量占剂量的41.4±10.5%。这可能是由于碘普罗胺的蛋白结合率低于碘帕醇。注射后2小时内两种非离子型造影剂的排泄量随年龄增长而持续下降。就碘普罗胺而言，25岁患者的平均排泄量占剂量的55%，而90岁患者则降至约40%（p<0.05）。文中讨论了观察到的差异和相关性的临床意义。
