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使用短时间心电图片段计算心律的非线性参数。

Computation of nonlinear parameters of heart rhythm using short time ECG segments.

作者信息

Koichubekov Berik, Korshukov Ilya, Omarbekova Nazgul, Riklefs Viktor, Sorokina Marina, Mkhitaryan Xenia

机构信息

Department of Medical Biophysics and Informatics, Karaganda State Medical University, Gogol Street 40, Karaganda 100008, Kazakhstan.

出版信息

Comput Math Methods Med. 2015;2015:983479. doi: 10.1155/2015/983479. Epub 2015 Jan 22.

Abstract

We propose the method to compute the nonlinear parameters of heart rhythm (correlation dimension D₂ and correlation entropy K₂) using 5-minute ECG recordings preferred for screening of population. Conversion of RR intervals' time series into continuous function x(t) allows getting the new time series with different sampling rate dt. It has been shown that for all dt (250, 200, 125, and 100 ms) the cross-plots of D₂ and K₂ against embedding dimension m for phase-space reconstruction start to level off at m = 9. The sample size N at different sampling rates varied from 1200 at dt = 250 ms to 3000 at dt = 100 ms. Along with, the D₂ and K₂ means were not statistically different; that is, the sampling rate did not influence the results. We tested the feasibility of the method in two models: nonlinear heart rhythm dynamics in different states of autonomous nervous system and age-related characteristics of nonlinear parameters. According to the acquired data, the heart rhythm is more complex in childhood and adolescence with more influential parasympathetic influence against the background of elevated activity of sympathetic autonomous nervous system.

摘要

我们提出了一种利用5分钟心电图记录来计算心律非线性参数(关联维数D₂和关联熵K₂)的方法,这种记录适用于人群筛查。将RR间期的时间序列转换为连续函数x(t),可以得到具有不同采样率dt的新时间序列。结果表明,对于所有的dt(250、200、125和100毫秒),用于相空间重构的D₂和K₂相对于嵌入维数m的交叉图在m = 9时开始趋于平稳。不同采样率下的样本量N从dt = 250毫秒时的1200变化到dt = 100毫秒时的3000。此外,D₂和K₂的均值在统计学上没有差异;也就是说,采样率不影响结果。我们在两个模型中测试了该方法的可行性:自主神经系统不同状态下的非线性心律动力学以及非线性参数的年龄相关特征。根据所获得的数据,在交感自主神经系统活动增强的背景下,儿童和青少年时期的心律更为复杂,副交感神经的影响更大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fe0/4320930/2de7ad12c01e/CMMM2015-983479.001.jpg

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