Jebors Said, Pinese Coline, Nottelet Benjamin, Parra Karine, Amblard Muriel, Mehdi Ahmad, Martinez Jean, Subra Gilles
Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, ENSCM, Université de Montpellier, 15 avenue Charles Flahault, 34000, Montpellier, France; Institut Charles Gerhardt, UMR5253 CNRS, ENSCM, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier, France.
J Pept Sci. 2015 Mar;21(3):243-7. doi: 10.1002/psc.2757. Epub 2015 Feb 16.
We have recently reported on a new class of silicone-peptide' biopolymers obtained by polymerization of di-functionalized chlorodimethylsilyl hybrid peptides. Herein, we describe a related strategy based on dichloromethylsilane-derived peptides, which yield novel polymers with a polysiloxane backbone, comparable with a silicone-bearing pendent peptide chains. Interestingly, polymerization is chemoselective toward amino acids side-chains and proceeds in a single step in very mild conditions (neutral pH, water, and room temperature). As potential application, a cationic sequence was polymerized and used for antibacterial coating.
我们最近报道了一类通过双官能化氯二甲基硅烷基杂合肽聚合得到的新型有机硅 - 肽生物聚合物。在此，我们描述了一种基于二氯甲基硅烷衍生肽的相关策略，该策略可产生具有聚硅氧烷主链的新型聚合物，与带有有机硅侧链的肽链相当。有趣的是，聚合反应对氨基酸侧链具有化学选择性，并且在非常温和的条件下（中性pH值、水和室温）一步进行。作为潜在应用，一种阳离子序列被聚合并用于抗菌涂层。
