Inotsume N, Nishimura M, Fujiyama S, Sagara K, Sato T, Imai Y, Matsui H, Nakano M
Department of Pharmaceutical Services, Kumamoto University Hospital, Japan.
Eur J Clin Pharmacol. 1989;36(5):517-20. doi: 10.1007/BF00558079.
The pharmacokinetics of the H2-receptor antagonist famotidine, after oral administration of a 20 mg tablet, has been studied in 10 elderly patients with normal renal function (CLCR greater than or equal to 59 ml.min-1, Mean = 80 ml.min-1), 5 elderly patients with renal insufficiency (CLCR less than or equal to 38 ml.min-1, Mean = 15 ml.min-1), and 6 healthy young volunteers. Elimination half-life in the elderly patients with renal insufficiency was significantly prolonged compared to the elderly patients with normal renal function and the young volunteers. The correlation coefficient between creatinine clearance and the elimination rate constant of famotidine was 0.672. Mean urinary recovery of unchanged drug up to 24 h in the young volunteers was 44%. The mean renal clearance of famotidine in the young volunteers (270 ml.min-1) was substantially greater than the creatinine clearance, 128 ml.min-1, which suggests the possibility of tubular secretion of famotidine.
在10名肾功能正常的老年患者（肌酐清除率CLCR大于或等于59 ml·min⁻¹，平均值 = 80 ml·min⁻¹）、5名肾功能不全的老年患者（CLCR小于或等于38 ml·min⁻¹，平均值 = 15 ml·min⁻¹）和6名健康年轻志愿者中，研究了口服20 mg法莫替丁片后的药代动力学。与肾功能正常的老年患者和年轻志愿者相比，肾功能不全的老年患者的消除半衰期显著延长。肌酐清除率与法莫替丁消除速率常数之间的相关系数为0.672。年轻志愿者中，直至24小时未变化药物的平均尿回收率为44%。年轻志愿者中法莫替丁的平均肾清除率（270 ml·min⁻¹）显著大于肌酐清除率128 ml·min⁻¹，这表明法莫替丁可能存在肾小管分泌。
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