空气污染物对常见自噬介导的衰老疾病中氧化应激的影响。
Impact of air pollutants on oxidative stress in common autophagy-mediated aging diseases.
作者信息
Numan Mohamed Saber, Brown Jacques P, Michou Laëtitia
机构信息
Department of Endocrinology and Nephrology, Centre Hospitalier Universitaire de Québec Research Centre, Québec, QC, G1V 4G2, Canada.
Division of Rheumatology, Department of Medicine, University Laval, Québec, QC, G1V 4G2, Canada.
出版信息
Int J Environ Res Public Health. 2015 Feb 17;12(2):2289-305. doi: 10.3390/ijerph120202289.
Abstract
Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's, disease, as well as Paget's disease of bone with or without frontotemporal dementia and inclusion body myopathy. Oxidative stress has serious damaging effects on the cellular contents: DNA, RNA, cellular proteins, and cellular organelles. Autophagy has a pivotal role in recycling these damaged non-functional organelles and misfolded or unfolded proteins. In this paper, we highlight, through a narrative review of the literature, that when autophagy processes are impaired during aging, in presence of cumulative air pollution-induced cellular oxidative stress and due to a direct effect on air pollutant, autophagy-mediated aging diseases may occur.
摘要
大气污染诱导的细胞氧化应激可能是大多数常见的自噬介导的衰老相关疾病的致病机制之一，这些疾病包括神经退行性疾病，如肌萎缩侧索硬化症（ALS）、阿尔茨海默病，以及伴有或不伴有额颞叶痴呆和包涵体肌病的佩吉特骨病。氧化应激对细胞成分（DNA、RNA、细胞蛋白和细胞器）具有严重的破坏作用。自噬在回收这些受损的无功能细胞器以及错误折叠或未折叠的蛋白质方面起着关键作用。在本文中，我们通过对文献的叙述性综述强调，在衰老过程中，当自噬过程受损时，在累积的空气污染诱导的细胞氧化应激存在的情况下，并且由于空气污染物的直接作用，可能会发生自噬介导的衰老相关疾病。
相似文献
1
Impact of air pollutants on oxidative stress in common autophagy-mediated aging diseases.空气污染物对常见自噬介导的衰老疾病中氧化应激的影响。
Int J Environ Res Public Health. 2015 Feb 17;12(2):2289-305. doi: 10.3390/ijerph120202289.
2
Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases.褪黑素与衰老相关神经退行性疾病中的自噬作用。
Int J Mol Sci. 2020 Sep 28;21(19):7174. doi: 10.3390/ijms21197174.
3
Astrocytes autophagy in aging and neurodegenerative disorders.星形胶质细胞自噬与衰老和神经退行性疾病。
Biomed Pharmacother. 2020 Feb;122:109691. doi: 10.1016/j.biopha.2019.109691. Epub 2019 Nov 28.
4
Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons.自噬调节神经元中与肌萎缩侧索硬化症相关的肉瘤融合阳性应激颗粒。
Neurobiol Aging. 2014 Dec;35(12):2822-2831. doi: 10.1016/j.neurobiolaging.2014.07.026. Epub 2014 Jul 27.
5
ER stress and impaired autophagy flux in neuronal degeneration and brain injury.内质网应激与自噬通量受损在神经元变性和脑损伤中的作用
Ageing Res Rev. 2017 Mar;34:3-14. doi: 10.1016/j.arr.2016.08.008. Epub 2016 Sep 1.
6
An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain.自噬在衰老和神经退行性脑的细胞反应中的作用的深入了解。
Histol Histopathol. 2012 Mar;27(3):263-75. doi: 10.14670/HH-27.263.
7
Oxidative stress-induced autophagy: role in pulmonary toxicity.氧化应激诱导的自噬：在肺毒性中的作用。
Toxicol Appl Pharmacol. 2014 Mar 1;275(2):145-51. doi: 10.1016/j.taap.2013.12.022. Epub 2014 Jan 4.
8
Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy.衰老与神经退行性疾病中的自噬：对发病机制及治疗的启示
Neurobiol Aging. 2014 May;35(5):941-57. doi: 10.1016/j.neurobiolaging.2013.11.019. Epub 2013 Nov 28.
9
Autophagy and ALS: mechanistic insights and therapeutic implications.自噬与肌萎缩侧索硬化症：机制见解与治疗意义。
Autophagy. 2022 Feb;18(2):254-282. doi: 10.1080/15548627.2021.1926656. Epub 2021 May 31.
10
Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress.自噬作为赋予对环境诱导的氧化应激抗性的第二级保护过程。
Autophagy. 2008 Feb;4(2):254-6. doi: 10.4161/auto.5528. Epub 2008 Jan 7.
引用本文的文献
1
From Inhalation to Neurodegeneration: Air Pollution as a Modifiable Risk Factor for Alzheimer's Disease.从吸入到神经退行性变：空气污染作为阿尔茨海默病的可改变风险因素。
Int J Mol Sci. 2024 Jun 25;25(13):6928. doi: 10.3390/ijms25136928.
2
Global challenges in aging: insights from comparative biology and one health.衰老领域的全球挑战：来自比较生物学和“同一健康”理念的见解
Front Toxicol. 2024 May 30;6:1381178. doi: 10.3389/ftox.2024.1381178. eCollection 2024.
3
Impact of Global Climate Change on Pulmonary Health: Susceptible and Vulnerable Populations.全球气候变化对肺部健康的影响：易感和脆弱人群。
Ann Am Thorac Soc. 2023 Aug;20(8):1088-1095. doi: 10.1513/AnnalsATS.202212-996CME.
4
Effects of Air Pollution on Cellular Senescence and Skin Aging.空气污染对细胞衰老和皮肤老化的影响。
Cells. 2022 Jul 17;11(14):2220. doi: 10.3390/cells11142220.
5
Comprehensive Review Regarding Mercury Poisoning and Its Complex Involvement in Alzheimer's Disease.关于汞中毒及其与阿尔茨海默病复杂关联的综合综述。
Int J Mol Sci. 2022 Feb 11;23(4):1992. doi: 10.3390/ijms23041992.
6
Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution.环境风险因素交通噪声和空气污染对昼夜节律的氧化还原调节变化。
Antioxid Redox Signal. 2022 Oct;37(10-12):679-703. doi: 10.1089/ars.2021.0272. Epub 2022 Apr 18.
7
Particulate Air Pollution and Risk of Neuropsychiatric Outcomes. What We Breathe, Swallow, and Put on Our Skin Matters.颗粒物空气污染与神经精神健康结局风险。吸入、咽下和接触的物质都很重要。
Int J Environ Res Public Health. 2021 Nov 3;18(21):11568. doi: 10.3390/ijerph182111568.
8
Lysosomes, Autophagy, and Hormesis in Cell Physiology, Pathology, and Age-Related Disease.细胞生理学、病理学及衰老相关疾病中的溶酶体、自噬与兴奋效应
Dose Response. 2020 Jul 7;18(3):1559325820934227. doi: 10.1177/1559325820934227. eCollection 2020 Jul-Sep.
9
Altered Features of Vimentin-containing Cells in Cerebrum of Tg(SOD1*G93A)1Gur Mice: A Preliminary Study on Cerebrum Endogenous Neural Precursor Cells in Amyotrophic Lateral Sclerosis.转铁蛋白（Vimentin）阳性细胞在 Tg(SOD1*G93A)1Gur 脑内的改变：肌萎缩侧索硬化症脑内内源性神经前体细胞的初步研究。
Int J Biol Sci. 2019 Nov 1;15(13):2830-2843. doi: 10.7150/ijbs.33461. eCollection 2019.
10
A general neurologist's perspective on the urgent need to apply resilience thinking to the prevention and treatment of Alzheimer's disease.一位普通神经科医生对将复原力思维应用于阿尔茨海默病预防和治疗的迫切需求的看法。
Alzheimers Dement (N Y). 2017 Sep 12;3(4):498-506. doi: 10.1016/j.trci.2017.08.001. eCollection 2017 Nov.
本文引用的文献
1
Autophagy in the physiology and pathology of the central nervous system.自噬在中枢神经系统的生理与病理过程中的作用
Cell Death Differ. 2015 Mar;22(3):398-407. doi: 10.1038/cdd.2014.204. Epub 2014 Dec 19.
2
Pathobiology of Paget's Disease of Bone.骨佩吉特病的病理生物学
J Bone Metab. 2014 May;21(2):85-98. doi: 10.11005/jbm.2014.21.2.85. Epub 2014 May 31.
3
Oxidative stress and aging diseases.氧化应激与衰老相关疾病。
Oxid Med Cell Longev. 2014;2014:569146. doi: 10.1155/2014/569146. Epub 2014 May 12.
4
A national case-crossover analysis of the short-term effect of PM2.5 on hospitalizations and mortality in subjects with diabetes and neurological disorders.一项关于PM2.5对糖尿病和神经疾病患者住院及死亡率短期影响的全国性病例交叉分析。
Environ Health. 2014 May 22;13(1):38. doi: 10.1186/1476-069X-13-38.
5
Important role of autophagy in regulation of metabolic processes in health, disease and aging.自噬在健康、疾病和衰老过程中代谢调节中的重要作用。
Physiol Res. 2014;63(4):409-20. doi: 10.33549/physiolres.932684. Epub 2014 Apr 3.
6
Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy.衰老与神经退行性疾病中的自噬：对发病机制及治疗的启示
Neurobiol Aging. 2014 May;35(5):941-57. doi: 10.1016/j.neurobiolaging.2013.11.019. Epub 2013 Nov 28.
7
Autophagy and human diseases.自噬与人类疾病。
Cell Res. 2014 Jan;24(1):69-79. doi: 10.1038/cr.2013.161. Epub 2013 Dec 10.
8
Autophagy and apoptosis dysfunction in neurodegenerative disorders.神经退行性疾病中的自噬和细胞凋亡功能障碍。
Prog Neurobiol. 2014 Jan;112:24-49. doi: 10.1016/j.pneurobio.2013.10.004. Epub 2013 Nov 6.
9
SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis.法国额颞叶痴呆或额颞叶痴呆伴运动神经元病患者的 SQSTM1 突变。
JAMA Neurol. 2013 Nov;70(11):1403-10. doi: 10.1001/jamaneurol.2013.3849.
10
Sequestosome-1 (SQSTM1) sequence variants in ALS cases in the UK: prevalence and coexistence of SQSTM1 mutations in ALS kindred with PDB.英国肌萎缩侧索硬化症（ALS）病例中的聚集体结合蛋白1（SQSTM1）序列变异：ALS家族中SQSTM1突变与佩吉特骨病（PDB）的共存情况及患病率
Eur J Hum Genet. 2014 Apr;22(4):492-6. doi: 10.1038/ejhg.2013.184. Epub 2013 Aug 14.
Zotero 插件