Eiros-Bouza Jose Ma, Pérez-Rubio Alberto
Alberto Pérez Rubio. Dirección Médica. Hospital Clínico Universitario de Valladolid. Calle Ramón y Cajal 3, 47001. Valladolid, Spain.
Rev Esp Quimioter. 2015 Feb;28(1):39-46.
Since the 80s two lineages of type B viruses are co - circulating in the world. Antigenic differences between them are important and it leads to lack of cross-reactivity. The impact on the burden of disease due to influenza B virus, poor foresight in estimating which of the two lineages of B viruses circulate in the season, and the consequent lack of immunity in case of including the wrong strain make that the availability of the quadrivalent vaccine is very useful. The aim of this paper is to analyze the past influenza seasons in Spain to assess the burden of disease, divergence between the vaccine strain and the circulating B and viral characteristics associated with type B in each seasonal epidemic.
Review of all reports issued by the Influenza Surveillance System in Spain since the 2003-2004 season to 2012-2013.
Over the past influenza seasons, although type A was present mostly, circulation of influenza B virus in each season was observed, even being co - dominant in some of them. In a high number of seasons the divergence between the vaccine strain and the circulating strain lineage has been observed
The protective effect of influenza vaccine has varied depending on the type / subtype of influenza virus studied. The vaccine effectiveness against influenza infection by influenza B virus has varied greatly depending on the season analyzed.
自80年代以来，两种B型流感病毒谱系在全球共同流行。它们之间的抗原差异很重要，这导致缺乏交叉反应性。B型流感病毒对疾病负担的影响、对某个季节中两种B型流感病毒谱系中哪一种会流行的预测不足，以及如果包含错误毒株会导致缺乏免疫力，使得四价疫苗的可用性非常有用。本文的目的是分析西班牙过去的流感季节，以评估疾病负担、疫苗毒株与流行的B型毒株之间的差异以及每个季节性流行中与B型相关的病毒特征。
回顾西班牙流感监测系统自2003 - 2004季节至2012 - 2013季节发布的所有报告。
在过去的流感季节中，虽然甲型流感病毒大多存在，但每个季节都观察到了B型流感病毒的流行，甚至在某些季节中呈共同主导地位。在大量季节中，观察到了疫苗毒株与流行毒株谱系之间的差异。
流感疫苗的保护效果因所研究的流感病毒类型/亚型而异。针对B型流感病毒感染的疫苗效力因所分析的季节而有很大差异。
