a Dirección Médica, Hospital Clínico Universitario de Valladolid , Spain.
b Servicio Microbiología, Hospital Universitario Rio Hortega , Valladolid , Spain.
Hum Vaccin Immunother. 2018;14(8):1874-1882. doi: 10.1080/21645515.2018.1460297. Epub 2018 Jun 28.
The benefit of influenza vaccines is difficult to estimate due to the complexity of accurately assessing the burden of influenza. To improve the efficacy of influenza vaccines, vaccine manufacturers have developed quadrivalent influenza vaccine (QIV) formulations for seasonal vaccination by including both influenza B lineages. Three parallel approaches for producing influenza vaccines are attracting the interest of many vaccine manufacturing companies. The first and oldest is the conventional egg-derived influenza vaccine, which is used by the current licensed influenza vaccines. The second approach is a cell culture-derived influenza vaccine, and the third and most recent is synthetic vaccines. Here, we analyze the difficulties with vaccines production in eggs and compare this to cell culture-derived influenza vaccines and discuss the future of cell culture-derived QIVs.
由于准确评估流感负担的复杂性,流感疫苗的益处难以评估。为了提高流感疫苗的效力,疫苗制造商通过包含两种乙型流感谱系,开发了用于季节性接种的四价流感疫苗(QIV)配方。三种生产流感疫苗的平行方法引起了许多疫苗制造公司的兴趣。第一种也是最古老的方法是传统的鸡蛋衍生流感疫苗,目前的授权流感疫苗都使用这种疫苗。第二种方法是细胞培养衍生的流感疫苗,第三种也是最新的方法是合成疫苗。在这里,我们分析了在鸡蛋中生产疫苗的困难,并将其与细胞培养衍生的流感疫苗进行了比较,并讨论了细胞培养衍生的 QIV 的未来。