Ünal Betül, Alan Sevil, Başsorgun Cumhur İbrahim, Karakaş Ayşe Akman, Elpek Gülsüm Özlem, Çiftçioğlu Mehmet Akif
Department of Pathology, School of Medicine, Akdeniz University, Antalya, Turkey,
Arch Dermatol Res. 2015 Sep;307(7):551-7. doi: 10.1007/s00403-015-1546-2. Epub 2015 Feb 18.
GDF-15 (Growth Differentiation Factor-15) is a member of the transforming growth factor β (TGF-β) superfamily. GDF-15 is not only involved in cancer development, progression, angiogenesis and metastasis, but also controls stress responses, bone formation, hematopoietic development, adipose tissue function and cardiovascular diseases. GDF-15, which is regulated by p53, has shown antitumorigenic and proapoptotic activities in vivo and in vitro. Also, GDF-15 is involved in skin biology and histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and metastasis. GDF-15 level is increased in patients with systemic sclerosis and is related with the degree of skin sclerosis and intensity of pulmonary fibrosis. In the future, GDF-15 may be a potential target for therapy in benign disorders with skin fibrosis and malignant lesions of the skin.
生长分化因子15（GDF - 15）是转化生长因子β（TGF - β）超家族的成员。GDF - 15不仅参与癌症的发生、发展、血管生成和转移，还控制应激反应、骨形成、造血发育、脂肪组织功能和心血管疾病。由p53调控的GDF - 15在体内和体外均表现出抗肿瘤和促凋亡活性。此外，GDF - 15参与皮肤生物学和组胺诱导的黑色素生成；它在黑色素瘤细胞中过度表达，并与肿瘤侵袭和转移的深度相关。系统性硬化症患者的GDF - 15水平升高，且与皮肤硬化程度和肺纤维化强度有关。未来，GDF - 15可能成为治疗皮肤纤维化良性疾病和皮肤恶性病变的潜在靶点。
