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Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo.

作者信息

Ishiyama Aki, Iwatsuki Masato, Hokari Rei, Sawa Masaaki, Ōmura Satoshi, Otoguro Kazuhiko

机构信息

1] Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan [2] Graduate School of Infection Control Sciences, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.

Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 2015 Jul;68(7):469-72. doi: 10.1038/ja.2015.7. Epub 2015 Feb 18.

DOI:10.1038/ja.2015.7
PMID:25690362
Abstract
摘要

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本文引用的文献

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J Infect Dis. 2014 Aug 1;210(3):335-7. doi: 10.1093/infdis/jiu142. Epub 2014 Mar 8.
2
Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.开发强效且选择性的恶性疟原虫钙依赖性蛋白激酶4(PfCDPK4)抑制剂,以阻断疟疾向蚊子的传播。
Eur J Med Chem. 2014 Mar 3;74:562-73. doi: 10.1016/j.ejmech.2013.12.048. Epub 2014 Jan 11.
3
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.
尼洛替尼:一种通过调节自噬介导细胞内分枝杆菌耐药的酪氨酸激酶抑制剂。
Cells. 2019 May 26;8(5):506. doi: 10.3390/cells8050506.
青蒿素耐药恶性疟原虫的一个分子标记。
Nature. 2014 Jan 2;505(7481):50-5. doi: 10.1038/nature12876. Epub 2013 Dec 18.
4
Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum.全球人类疟原虫恶性疟原虫的蛋白质组学和磷酸化蛋白质组学分析。
Nat Commun. 2011 Nov 29;2:565. doi: 10.1038/ncomms1558.
5
Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration.综述了静脉、肌肉、口服和直肠给药后青蒿琥酯及其活性代谢物双氢青蒿素的临床药代动力学。
Malar J. 2011 Sep 13;10:263. doi: 10.1186/1475-2875-10-263.
6
First-line treatment for chronic myeloid leukemia: dasatinib, nilotinib, or imatinib.慢性髓性白血病的一线治疗:达沙替尼、尼洛替尼或伊马替尼。
J Hematol Oncol. 2010 Nov 26;3:47. doi: 10.1186/1756-8722-3-47.
7
Targeting the cancer kinome through polypharmacology.通过多药理学靶向癌症激酶组。
Nat Rev Cancer. 2010 Feb;10(2):130-7. doi: 10.1038/nrc2787.
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Clinical pharmacokinetics of the BCR-ABL tyrosine kinase inhibitor nilotinib.尼洛替尼的 BCR-ABL 酪氨酸激酶抑制剂的临床药代动力学。
Clin Pharmacol Ther. 2010 Feb;87(2):197-203. doi: 10.1038/clpt.2009.208. Epub 2009 Nov 18.
9
Malaria: targeting parasite and host cell kinomes.疟疾:靶向疟原虫和宿主细胞的激酶组
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