• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004.1990年至2004年分离株中的耐抗生素肺炎克雷伯菌和大肠杆菌高危克隆以及携带Tn1（blaTEM-4）的IncFII(k)嵌合质粒
Antimicrob Agents Chemother. 2015 May;59(5):2904-8. doi: 10.1128/AAC.00296-15. Epub 2015 Feb 17.
2
Characteristics of plasmid-mediated quinolone resistance genes in extended-spectrum cephalosporin-resistant isolates of Klebsiella pneumoniae and Escherichia coli in Korea.韩国产超广谱头孢菌素耐药肺炎克雷伯菌和大肠埃希菌中质粒介导的喹诺酮耐药基因的特征。
Chemotherapy. 2010;56(1):46-53. doi: 10.1159/000290972. Epub 2010 Mar 4.
3
Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae.肺炎克雷伯菌临床分离株中QnrB决定簇与超广谱β-内酰胺酶或质粒介导的AmpCβ-内酰胺酶产生的相关性
Antimicrob Agents Chemother. 2007 Jan;51(1):366-8. doi: 10.1128/AAC.00841-06. Epub 2006 Oct 30.
4
Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug-resistant epidemic Klebsiella pneumoniae strain.质粒 pKpQIL 编码 KPC-3 和 TEM-1，赋予了一株具有极强耐药性的流行肺炎克雷伯菌对碳青霉烯类药物的耐药性。
J Antimicrob Chemother. 2010 Feb;65(2):243-8. doi: 10.1093/jac/dkp417. Epub 2009 Nov 24.
5
Co-production of SFO-1 and DHA-1 β-lactamases and 16S rRNA methylase ArmA in clinical isolates of Klebsiella pneumoniae.产 SFO-1 和 DHA-1β-内酰胺酶以及 16S rRNA 甲基化酶 ArmA 的肺炎克雷伯菌临床分离株的协同产生。
J Antimicrob Chemother. 2012 Oct;67(10):2361-6. doi: 10.1093/jac/dks244. Epub 2012 Jul 9.
6
Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit.新生儿重症监护病房中产超广谱β-内酰胺酶肺炎克雷伯菌的分子流行病学
J Antimicrob Chemother. 2006 May;57(5):979-82. doi: 10.1093/jac/dkl077. Epub 2006 Mar 10.
7
Molecular epidemiology of carbapenem resistant Enterobacteriaceae in Valle d'Aosta region, Italy, shows the emergence of KPC-2 producing Klebsiella pneumoniae clonal complex 101 (ST101 and ST1789).意大利瓦莱达奥斯塔地区耐碳青霉烯类肠杆菌科的分子流行病学研究显示，产 KPC-2 的肺炎克雷伯菌克隆复合体 101（ST101 和 ST1789）的出现。
BMC Microbiol. 2015 Nov 9;15(1):260. doi: 10.1186/s12866-015-0597-z.
8
Horizontal transfer of blaCMY-bearing plasmids among clinical Escherichia coli and Klebsiella pneumoniae isolates and emergence of cefepime-hydrolyzing CMY-19.携带blaCMY质粒在临床大肠杆菌和肺炎克雷伯菌分离株之间的水平转移以及头孢吡肟水解性CMY-19的出现。
Antimicrob Agents Chemother. 2006 Feb;50(2):534-41. doi: 10.1128/AAC.50.2.534-541.2006.
9
Insights into the evolution of gene organization and multidrug resistance from Klebsiella pneumoniae plasmid pKF3-140.从肺炎克雷伯氏菌质粒 pKF3-140 看基因组织和多重耐药性的进化。
Gene. 2013 Apr 25;519(1):60-6. doi: 10.1016/j.gene.2013.01.050. Epub 2013 Feb 9.
10
Plasmid-mediated 16S rRNA methylases conferring high-level aminoglycoside resistance in Escherichia coli and Klebsiella pneumoniae isolates from two Taiwanese hospitals.在来自台湾两家医院的大肠杆菌和肺炎克雷伯菌分离株中，质粒介导的16S rRNA甲基化酶赋予高水平氨基糖苷类耐药性
J Antimicrob Chemother. 2004 Dec;54(6):1007-12. doi: 10.1093/jac/dkh455. Epub 2004 Oct 14.

引用本文的文献

1
The ecological security risks of bronopol: a focus on antibiotic resistance gene dissemination.布罗波尔的生态安全风险：聚焦抗生素抗性基因传播
Front Microbiol. 2025 Jul 7;16:1595833. doi: 10.3389/fmicb.2025.1595833. eCollection 2025.
2
Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates.美国血流感染分离株中多重耐药或高毒力肺炎克雷伯菌的基因组监测。
BMC Infect Dis. 2022 Jul 7;22(1):603. doi: 10.1186/s12879-022-07558-1.
3
A 21-Year Survey of Escherichia coli from Bloodstream Infections (BSI) in a Tertiary Hospital Reveals How Community-Hospital Dynamics of B2 Phylogroup Clones Influence Local BSI Rates.21 年血流感染（BSI）中大肠杆菌的研究揭示了 B2 phylogroup 克隆的社区-医院动态如何影响当地 BSI 率。
mSphere. 2021 Dec 22;6(6):e0086821. doi: 10.1128/msphere.00868-21.
4
Phenotypic and genotypic characteristics of carbapenemase- and extended spectrum β-lactamase-producing clinical isolates within a hospital in Panama City.巴拿马城一家医院内产碳青霉烯酶和超广谱β-内酰胺酶临床分离株的表型和基因型特征
Ther Adv Infect Dis. 2021 Oct 30;8:20499361211054918. doi: 10.1177/20499361211054918. eCollection 2021 Jan-Dec.
5
Evolutionary Pathways and Trajectories in Antibiotic Resistance.抗生素耐药性的进化途径和轨迹。
Clin Microbiol Rev. 2021 Dec 15;34(4):e0005019. doi: 10.1128/CMR.00050-19. Epub 2021 Jun 30.

本文引用的文献

1
Plasmid flux in Escherichia coli ST131 sublineages, analyzed by plasmid constellation network (PLACNET), a new method for plasmid reconstruction from whole genome sequences.通过质粒星座网络（PLACNET，一种从全基因组序列重建质粒的新方法）分析大肠杆菌ST131亚系中的质粒通量。
PLoS Genet. 2014 Dec 18;10(12):e1004766. doi: 10.1371/journal.pgen.1004766. eCollection 2014 Dec.
2
A draft genome of Escherichia coli sequence type 127 strain 2009-46.大肠杆菌序列类型127菌株2009 - 46的基因组草图。
Gut Pathog. 2014 Sep 1;6:32. doi: 10.1186/1757-4749-6-32. eCollection 2014.
3
Expansion of ESBL-producing Klebsiella pneumoniae in hospitalized patients: a successful story of international clones (ST15, ST147, ST336) and epidemic plasmids (IncR, IncFIIK).产超广谱β-内酰胺酶肺炎克雷伯菌在住院患者中的传播：国际克隆株（ST15、ST147、ST336）和流行质粒（IncR、IncFIIK）的成功案例
Int J Med Microbiol. 2014 Nov;304(8):1100-8. doi: 10.1016/j.ijmm.2014.08.003. Epub 2014 Aug 13.
4
Epidemic Klebsiella pneumoniae ST258 is a hybrid strain.流行的肺炎克雷伯菌ST258是一种杂交菌株。
mBio. 2014 Jun 24;5(3):e01355-14. doi: 10.1128/mBio.01355-14.
5
Global dissemination of a multidrug resistant Escherichia coli clone.全球传播的一种多重耐药大肠杆菌克隆。
Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5694-9. doi: 10.1073/pnas.1322678111. Epub 2014 Mar 31.
6
Widespread dissemination of CTX-M-15 genotype extended-spectrum-β-lactamase-producing enterobacteriaceae among patients presenting to community hospitals in the southeastern United States.CTX-M-15 基因型产超广谱β-内酰胺酶肠杆菌科在东南美国家庭社区医院就诊患者中广泛传播。
Antimicrob Agents Chemother. 2014;58(2):1200-2. doi: 10.1128/AAC.01099-13. Epub 2013 Nov 18.
7
Antimicrobial resistance in human and animal pathogens in Zambia, Democratic Republic of Congo, Mozambique and Tanzania: an urgent need of a sustainable surveillance system.赞比亚、刚果民主共和国、莫桑比克和坦桑尼亚的人类和动物病原体中的抗微生物药物耐药性：建立可持续监测系统的迫切需要。
Ann Clin Microbiol Antimicrob. 2013 Oct 12;12:28. doi: 10.1186/1476-0711-12-28.
8
Large oligoclonal outbreak due to Klebsiella pneumoniae ST14 and ST26 producing the FOX-7 AmpC β-lactamase in a neonatal intensive care unit.新生儿重症监护病房中由产FOX-7 AmpC β-内酰胺酶的肺炎克雷伯菌ST14和ST26引起的大规模寡克隆暴发。
J Clin Microbiol. 2013 Dec;51(12):4067-72. doi: 10.1128/JCM.01982-13. Epub 2013 Oct 2.
9
Molecular epidemiology of Escherichia coli sequence type 131 and Its H30 and H30-Rx subclones among extended-spectrum-β-lactamase-positive and -negative E. coli clinical isolates from the Chicago Region, 2007 to 2010.2007 年至 2010 年期间，芝加哥地区产超广谱β-内酰胺酶和不产超广谱β-内酰胺酶的大肠杆菌临床分离株中大肠杆菌序列型 131 及其 H30 和 H30-Rx 亚克隆的分子流行病学研究。
Antimicrob Agents Chemother. 2013 Dec;57(12):6385-8. doi: 10.1128/AAC.01604-13. Epub 2013 Sep 30.
10
A nosocomial outbreak of KPC-2-producing Klebsiella pneumoniae in a Chinese hospital: dissemination of ST11 and emergence of ST37, ST392 and ST395.一家中国医院中产 KPC-2 的肺炎克雷伯菌的医院感染爆发：ST11 的传播和 ST37、ST392 和 ST395 的出现。
Clin Microbiol Infect. 2013 Nov;19(11):E509-15. doi: 10.1111/1469-0691.12275. Epub 2013 Jul 10.

1990年至2004年分离株中的耐抗生素肺炎克雷伯菌和大肠杆菌高危克隆以及携带Tn1（blaTEM-4）的IncFII(k)嵌合质粒

Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004.

作者信息

Rodríguez Irene, Novais Ângela, Lira Felipe, Valverde Aránzazu, Curião Tânia, Martínez José Luis, Baquero Fernando, Cantón Rafael, Coque Teresa M

机构信息

Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain CIBER en Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain UCIBIO/REQUIMTE, Laboratório de Microbiologia, Faculdade de Farmácia da Universidade do Porto, Porto, Portugal.

出版信息

Antimicrob Agents Chemother. 2015 May;59(5):2904-8. doi: 10.1128/AAC.00296-15. Epub 2015 Feb 17.

DOI:10.1128/AAC.00296-15
PMID:25691645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4394812/
Abstract

We describe the genetic background of bla(TEM-4) and the complete sequence of pRYC11::bla(TEM-4), a mosaic plasmid that is highly similar to pKpQIL-like variants, predominant among TEM-4 producers in a Spanish hospital (1990 to 2004), which belong to Klebsiella pneumoniae and Escherichia coli high-risk clones responsible for the current spread of different antibiotic resistance genes. Predominant populations of plasmids and host adapted clonal lineages seem to have greatly contributed to the spread of resistance to extended-spectrum cephalosporins.

摘要

我们描述了bla(TEM-4)的遗传背景以及pRYC11::bla(TEM-4)的完整序列，pRYC11::bla(TEM-4)是一种镶嵌质粒，与pKpQIL样变体高度相似，在一家西班牙医院（1990年至2004年）的TEM-4产生菌中占主导地位，这些产生菌属于肺炎克雷伯菌和大肠杆菌的高风险克隆，它们导致了不同抗生素抗性基因的当前传播。质粒的主要群体和宿主适应的克隆谱系似乎对超广谱头孢菌素耐药性的传播起到了很大作用。