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肺炎克雷伯菌临床分离株中QnrB决定簇与超广谱β-内酰胺酶或质粒介导的AmpCβ-内酰胺酶产生的相关性

Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae.

作者信息

Pai Hyunjoo, Seo Mi-Ran, Choi Tae Yeal

机构信息

Division of Infectious Diseases, College of Medicine, Hanyang University, Seoul 133-791, Korea.

出版信息

Antimicrob Agents Chemother. 2007 Jan;51(1):366-8. doi: 10.1128/AAC.00841-06. Epub 2006 Oct 30.

Abstract

Clinical isolates of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases were screened for qnrA and qnrB genes. QnrB was present in 54 of 54 DHA-1-producing K. pneumoniae isolates and 10 of 45 SHV-12-producing ones, suggesting that the distribution of plasmids conferring resistance to extended-spectrum cephalosporins and quinolones in clinical isolates of K. pneumoniae is widespread.

摘要

对产超广谱β-内酰胺酶或质粒介导的AmpCβ-内酰胺酶的大肠埃希菌和肺炎克雷伯菌临床分离株进行了qnrA和qnrB基因筛查。qnrB存在于54株产DHA-1的肺炎克雷伯菌分离株中的54株以及45株产SHV-12的分离株中的10株,这表明在肺炎克雷伯菌临床分离株中,赋予对超广谱头孢菌素和喹诺酮类耐药性的质粒分布广泛。

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