Terni Eva, Giannini Nicola, Chiti Alberto, Gialdini Gino, Orlandi Giovanni, Montano Vincenzo, Orsucci Daniele, Brondi Marco, Bonuccelli Ubaldo, Mancuso Michelangelo
Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Italy.
Blood Coagul Fibrinolysis. 2015 Jul;26(5):505-8. doi: 10.1097/MBC.0000000000000262.
Cerebral sinus venous thrombosis (CSVT) is a rare condition representing the 0.5-1% of all stroke cases which can have serious consequences. Early diagnosis and complete screening for acquired or inherited risk factors is crucial for decreasing morbidity and mortality. We have investigated clinical and aetiological factors in an Italian cohort of 43 patients with cerebral sinus venous thrombosis. Common presentation complaints were headache (81.4%), focal signs (20.9%), vomiting (11.6%) and seizures (6.9%). Acquired or inherited conditions were observed in more than 80% of cases. The commonest aetiological factors were contraceptives (74.1% of women), congenital thrombophilia (34.9%), infections and dysthyroidism (16.3%), hyperhomocysteinemia (9.3%), migraine (11.6%), cranial trauma (9.3%) and chronic myeloproliferative diseases (11.6%). Outcome was favourable in more than 80% of patients. Early diagnosis and anticoagulant treatment may decrease mortality and/or morbidity rates related with CVST in these patients. Thrombophilic abnormalities, either inherited or acquired, are worthy to be widely investigated.
脑静脉窦血栓形成（CSVT）是一种罕见疾病，占所有中风病例的0.5%-1%，可产生严重后果。对获得性或遗传性危险因素进行早期诊断和全面筛查对于降低发病率和死亡率至关重要。我们对意大利一组43例脑静脉窦血栓形成患者的临床和病因学因素进行了调查。常见的主诉症状有头痛（81.4%）、局灶性体征（20.9%）、呕吐（11.6%）和癫痫发作（6.9%）。80%以上的病例存在获得性或遗传性疾病。最常见的病因学因素是避孕药（74.1%的女性）、先天性血栓形成倾向（34.9%）、感染和甲状腺功能障碍（16.3%）、高同型半胱氨酸血症（9.3%）、偏头痛（11.6%）、颅脑外伤（9.3%）和慢性骨髓增殖性疾病（11.6%）。80%以上患者的预后良好。早期诊断和抗凝治疗可能会降低这些患者与脑静脉窦血栓形成相关的死亡率和/或发病率。遗传性或获得性血栓形成倾向异常值得广泛研究。
