Krasil'nikov M A, Bogdanova N N, Adler V V
Biokhimiia. 1989 Apr;54(4):656-61.
Single injections of rats with hydrocortisone led to the inhibition of regenerating liver cell proliferation and protooncogene++ Ha-ras mRNA synthesis within 48 hours of hormonal induction. Administration of hydrocortisone to rats daily for 10 days resulted in a persistent decrease of the liver cell capacity to proliferate in response to partial hepatectomy. This inhibiting effect was observed for at least 7 days after cessation of hormonal stimulation; the level of Ha-ras mRNA was thereby decreased. A marked inhibition of ascite hepatoma cell growth was demonstrated after injections of those cells to mice induced with hydrocortisone for 10 days. Such a persistent effect of hydrocortisone is thought to be due to the depletion of the hormone-dependent hepatotrophic factors. The effect of the glucocorticoid hormone in vivo can be supposed to involve both the direct and indirect regulation of target cell proliferation. The latter is mediated via the changes in the activity of exogenous factors which control cell growth and proliferation.
给大鼠单次注射氢化可的松会在激素诱导后的48小时内抑制再生肝细胞增殖和原癌基因Ha-ras mRNA的合成。对大鼠连续10天每日给予氢化可的松，会导致肝细胞对部分肝切除的增殖反应能力持续下降。在激素刺激停止后至少7天观察到这种抑制作用；Ha-ras mRNA的水平因此降低。在用氢化可的松诱导10天的小鼠中注射腹水肝癌细胞后，显示出对其生长的显著抑制。氢化可的松的这种持续作用被认为是由于激素依赖性肝营养因子的耗竭。糖皮质激素在体内的作用可能涉及对靶细胞增殖的直接和间接调节。后者是通过控制细胞生长和增殖的外源性因子活性的变化介导的。
