Ganem Kh, Zlateva M, Popov A
Eksp Med Morfol. 1989;28(2):32-5.
The amount of some endocrine cells in various forms of chronic gastritis with and without the presence of intestinal metaplasia of the stomach mucosa was studied immunohistochemically (PAP-reaction). The study was carried out on 18 samples of biopsied material for D-cells and on 31--for G cells. It was established that the amount of these cells as well as their ratio was changed in accordance with the form of chronic gastritis. Thus, for example++ , the number of D-cells was increased in mild forms of gastritis, but they were reduced in its grave form, while the number of G-cells gradually diminished from mild to grave forms. These changes give foundation to assume that hr hormonal disturbance of the stomach mucosa plays important role in pathogenesis of this disease. This suggestion is supported by the observed in dynamics quantitative changes of these cells, beginning even at the initial stages of this disease.
采用免疫组织化学方法（PAP反应）研究了胃黏膜存在或不存在肠化生的各种慢性胃炎中某些内分泌细胞的数量。对18份活检材料样本进行了D细胞研究，对31份活检材料样本进行了G细胞研究。结果表明，这些细胞的数量及其比例根据慢性胃炎的类型而发生变化。例如，在轻度胃炎中D细胞数量增加，但在重度胃炎中减少，而G细胞数量则从轻度到重度逐渐减少。这些变化使人们有理由认为胃黏膜的激素紊乱在该疾病的发病机制中起重要作用。这些细胞动态定量变化的观察结果支持了这一观点，甚至在该疾病的初始阶段就已开始出现这种变化。
