Goyal Surbhi, Parihar Asmita, Puri Vandana, Sharma Naveen, Goyal Ankur, Arora Vinod Kumar
Department of Pathology, University College of Medical Sciences & GTB Hospital, Delhi, India.
Diagn Cytopathol. 2015 Jun;43(6):490-4. doi: 10.1002/dc.23267. Epub 2015 Feb 19.
Malakoplakia is a rare chronic granulomatous inflammatory disease, related to immune deficiency and impaired bactericidal macrophage activity. Common sites of involvement include urinary bladder and kidney followed by gastrointestinal tract. We present an unusual case of abdominal malakoplakia diagnosed preoperatively on ultrasound-guided fine-needle aspiration cytology (FNAC). It presented as a large locally aggressive mass with extensive involvement of multiple bowel loops in an 18-year-old boy following blunt trauma to the abdomen. The demonstration of calcified laminated intracytoplasmic Michaelis-Gutman bodies in histiocytes is a reliable diagnostic feature of malakoplakia on FNAC smears, which can guide an appropriate medical management.
软斑病是一种罕见的慢性肉芽肿性炎症性疾病,与免疫缺陷和巨噬细胞杀菌活性受损有关。常见受累部位包括膀胱和肾脏,其次是胃肠道。我们报告一例罕见的腹部软斑病病例,术前通过超声引导下细针穿刺抽吸细胞学检查(FNAC)确诊。该病例表现为一名18岁男孩腹部钝性外伤后出现的一个巨大的局部侵袭性肿块,多个肠袢广泛受累。组织细胞内钙化层状的米氏小体在FNAC涂片上是软斑病可靠的诊断特征,可指导适当的医疗处理。