一名患有反复毛细支气管炎发作的儿童发生播散性鼻病毒C8感染，血液中存在感染性病毒并导致致命后果。
Disseminated rhinovirus C8 infection with infectious virus in blood and fatal outcome in a child with repeated episodes of bronchiolitis.
作者信息
Lupo Julien, Schuffenecker Isabelle, Morel-Baccard Christine, Bardet Julie, Payen Valérie, Kaiser Laurent, Constant Samuel, Lobrinus Johannes Alexander, Lin-Marq Nathalie, Lina Bruno, Morand Patrice, Tapparel Caroline
机构信息
Laboratory of Virology, University Hospital of Grenoble, Grenoble, France Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, Grenoble, France
French National Enterovirus/Parechovirus Reference Centre, Hospices Civils de Lyon, Lyon, France.
出版信息
J Clin Microbiol. 2015 May;53(5):1775-7. doi: 10.1128/JCM.03484-14. Epub 2015 Feb 18.
Abstract
We report a fatal case of acute lower respiratory tract disease with human rhinovirus C (HRV-C) as the unique cause in a 19-month-old girl with a history of repeated episodes of bronchiolitis. HRV-C type 8 nucleic acids were observed in respiratory, stool, and cerebrospinal fluid samples, and infectious virions were isolated from patient serum after inoculation onto reconstituted airway epithelia.
摘要
我们报告了一例19个月大、有反复毛细支气管炎病史的女童因人类鼻病毒C（HRV-C）作为唯一病因导致急性下呼吸道疾病死亡的病例。在呼吸道、粪便和脑脊液样本中检测到HRV-C 8型核酸，将患者血清接种到重组气道上皮细胞后从中分离出感染性病毒粒子。
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