澳大利亚首例致命性牙龈哈氏线虫性脑膜脑炎人类病例。
First human case of fatal Halicephalobus gingivalis meningoencephalitis in Australia.
作者信息
Lim Chuan Kok, Crawford April, Moore Casey V, Gasser Robin B, Nelson Renjy, Koehler Anson V, Bradbury Richard S, Speare Rick, Dhatrak Deepak, Weldhagen Gerhard F
机构信息
Department of Microbiology, SA Pathology, Adelaide, South Australia, Australia The University of Adelaide, Adelaide, South Australia, Australia
Department of Histopathology, SA Pathology, Adelaide, South Australia, Australia.
出版信息
J Clin Microbiol. 2015 May;53(5):1768-74. doi: 10.1128/JCM.00032-15. Epub 2015 Feb 18.
Abstract
Halicephalobus gingivalis (previously Micronema deletrix) is a free-living nematode known to cause opportunistic infections, mainly in horses. Human infections are very rare, but all cases described to date involved fatal meningoencephalitis. Here we report the first case of H. gingivalis infection in an Australian human patient, confirmed by nematode morphology and sequencing of ribosomal DNA. The implications of this case are discussed, particularly, the need to evaluate real-time PCR as a diagnostic tool.
摘要
牙龈哈尔夫线虫（以前称为微小线虫）是一种自由生活的线虫，已知会引起机会性感染，主要发生在马匹身上。人类感染非常罕见，但迄今为止描述的所有病例均涉及致命性脑膜脑炎。在此，我们报告澳大利亚一名人类患者感染牙龈哈尔夫线虫的首例病例，该病例通过线虫形态学和核糖体DNA测序得以确诊。本文讨论了该病例的影响，尤其是评估实时PCR作为诊断工具的必要性。
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