Departamento de Patología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México.
Departamento de Medicina, Cirugía y Zootecnia de Equinos, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México.
Vet Parasitol Reg Stud Reports. 2020 Apr;20:100399. doi: 10.1016/j.vprsr.2020.100399. Epub 2020 Mar 18.
Aberrant nematode larval migration in the CNS of horses is rare but frequently fatal; one of the main etiological agents involved in this illness is Halicephalobus gingivalis. This soil nematode has been associated with several fatal equine meningoencephalitis reports worldwide; however, it had never been diagnosed in horses of Mexico. A 10 year-old Andalusian horse presented dysphagia, fever, weakness, prostration and ataxia; the patient expired during the medical attention. Post mortem examination was performed and no gross alterations were found. Histopathology revealed meningoencephalitis, vasculitis and intralesional adult nematodes, larvae and eggs compatible with Halicephalobus spp. A polymerase chain reaction (PCR) for the nuclear large subunit ribosomal RNA gene (LSU rDNA) of nematodes was performed from formalin-fixed and paraffin wax-embedded sections of brain. Posterior nucleotide sequence analysis of the amplified fragment identified the agent as H. gingivalis. To our knowledge, this is the first confirmed report of Halicephalobiasis in Mexico.
中枢神经系统内异常的线虫幼虫迁移在马中较为罕见，但常是致命的；导致这种疾病的主要病原体之一是齿冠食道口线虫。这种土壤线虫与世界范围内几例致命性马属动物脑膜脑炎报告有关；然而，在墨西哥的马中从未诊断出过。一匹 10 岁的安达卢西亚马表现出吞咽困难、发热、虚弱、衰竭和共济失调；该患者在治疗过程中死亡。进行了剖检，但未发现明显的改变。组织病理学显示脑膜脑炎、血管炎和病灶内有成年线虫、幼虫和卵，与齿冠食道口线虫属相符。对脑组织的福尔马林固定和石蜡包埋切片进行了针对线虫核大亚基核糖体 RNA 基因（LSU rDNA）的聚合酶链反应（PCR）。扩增片段的后核苷酸序列分析将该病原体鉴定为齿冠食道口线虫。据我们所知，这是墨西哥首例齿冠食道口线虫病的确诊报告。
