LaPorte Justin, Morris Lawrence, Koepke John
The Blood and Marrow Transplant Program at Northside Hospital, Atlanta, GA 30342, USA.
Northside Hospital Pathology Department, Atlanta, GA 30342, USA.
Case Rep Hematol. 2015;2015:715615. doi: 10.1155/2015/715615. Epub 2015 Jan 28.
Aggressive natural killer cell leukemia (ANKL) is a rare and often lethal lymphoproliferative disorder. Patients may present with constitutional symptoms, jaundice, skin infiltration, lymphadenopathy, and hepatosplenomegaly. ANKL can progress quickly to multiorgan failure and survival is usually measured in weeks. Although a rapid and accurate diagnosis is critical, unfortunately there is no hallmark diagnostic marker of ANKL. We report a case of a 48-year-old male who was able to obtain a complete remission following cisplatin-based chemotherapy. We describe the details of the chemotherapy regimens used and a literature review of the treatment of ANKL.
侵袭性自然杀伤细胞白血病（ANKL）是一种罕见且通常致命的淋巴增殖性疾病。患者可能出现全身症状、黄疸、皮肤浸润、淋巴结病和肝脾肿大。ANKL可迅速进展为多器官功能衰竭，生存期通常以周计算。尽管快速准确的诊断至关重要，但不幸的是，ANKL没有标志性的诊断标志物。我们报告一例48岁男性患者，其在基于顺铂的化疗后获得了完全缓解。我们描述了所使用的化疗方案细节，并对ANKL的治疗进行了文献综述。
