Donato Umberto M, Shoeleh Celeste, Galligan Andrew
Pediatric Hematology Oncology, University of South Florida Morsani College of Medicine, Tampa, USA.
Pediatric Oncology, Moffitt Cancer Center, Tampa, USA.
Cureus. 2022 Jun 3;14(6):e25634. doi: 10.7759/cureus.25634. eCollection 2022 Jun.
Aggressive natural killer cell leukemia (ANKL) is a rare neoplastic malignancy, especially in pediatric populations with very few cases reported in the literature. It commonly presents with a rapidly declining clinical course and has a median survival of two months. We report the case of a 15-year-old female who presented with fever, hepatosplenomegaly, hemophagocytosis, and disseminated intravascular coagulation (DIC). The patient was ultimately diagnosed with ANKL but died after developing multiorgan failure and DIC prior to the initiation of any treatment. In this case report, we review and discuss the literature concerning the diagnosis and treatment of ANKL in pediatric patients.
侵袭性自然杀伤细胞白血病（ANKL）是一种罕见的肿瘤性恶性疾病，尤其是在儿科人群中，文献报道的病例极少。它通常表现为临床病程迅速恶化，中位生存期为两个月。我们报告了一例15岁女性患者，她出现发热、肝脾肿大、噬血细胞增多和弥散性血管内凝血（DIC）。该患者最终被诊断为ANKL，但在开始任何治疗之前就因多器官功能衰竭和DIC而死亡。在本病例报告中，我们回顾并讨论了有关儿科患者ANKL诊断和治疗的文献。
