Shojamoradi Mohammad Hossein, Saberi Isfeedvajani Mohsen, Mahdavi-Mazdeh Mitra, Ahmadi Farrokhlagha, Gatmiri Seyed Mansour, Abbasi Larki Rozina
Nephrology Research Center, Tehran University of Medical Sciences, Tehran, IR Iran.
Medicine, Quran and Hadith Research Center, Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Nephrourol Mon. 2014 Sep 5;6(5):e20748. doi: 10.5812/numonthly.20748. eCollection 2014 Sep.
In the past few decades, Chronic Kidney Disease (CKD) - a disease with progressive decline in renal function - has become an important problem of global public health, not only in developed countries, but also in developing countries with less economic power.
In this study, CKD progression to death or End Stage Renal Disease (ESRD) in elderly Iranian patients was compared with younger counterparts.
This retrospective cohort study was conducted on CKD patients with estimated Glomerular Filtration Rate (eGFR) < 60 mL/min, in a nephrology clinic in Tehran from December of 2006 until December of 2012. eGFR trend, death and need to renal replacement therapy (RRT) were evaluated as outcomes and compared between patients younger and older than 60 years. Data were analyzed using SPSS version 13.
Five-hundred and two patients were enrolled and followed up for an average of 37.6 months. Two thirds of the patients were older than 60 years. The incidence density of ESRD in patients younger and older than 60 years were 6.3 and 3.6 for 100 persons per year, respectively. Younger ones showed more rapid decline in their eGFR, while older patients had more stable renal function.
It seems necessary to conduct more researches in order to redefine CKD and identify its prognostic markers in elderly population.
在过去几十年中，慢性肾脏病（CKD）——一种肾功能逐渐衰退的疾病——已成为一个重要的全球公共卫生问题，不仅在发达国家如此，在经济实力较弱的发展中国家也是如此。
在本研究中，对伊朗老年患者与年轻患者的慢性肾脏病进展至死亡或终末期肾病（ESRD）的情况进行了比较。
这项回顾性队列研究于2006年12月至2012年12月在德黑兰一家肾脏病诊所对估计肾小球滤过率（eGFR）<60 mL/分钟的慢性肾脏病患者进行。将eGFR趋势、死亡情况以及肾脏替代治疗（RRT）需求作为观察指标进行评估，并在60岁及以上和60岁以下的患者之间进行比较。使用SPSS 13版软件对数据进行分析。
共纳入502例患者，平均随访37.6个月。三分之二的患者年龄超过60岁。60岁及以下和60岁以上患者的终末期肾病发病密度分别为每年每100人6.3例和3.6例。年轻患者的eGFR下降更快，而老年患者的肾功能更稳定。
似乎有必要开展更多研究，以便重新界定慢性肾脏病并确定其在老年人群中的预后标志物。
