Riou G, Barrois M, Sheng Z M, Duvillard P, Lhomme C
Laboratoire de Pharmacologie Clinique et Moléculaire, Institut Gustave Roussy, Villejuif, France.
Oncogene. 1988 Sep;3(3):329-33.
The c-Ha-ras-1 locus was analysed in cervical cancers and shown to exhibit the loss of one allele in 36% of heterozygous tumours and a mutation at codon 12 in 24% of tumours at advanced stages. 40% of tumours with mutation contained also a deletion. A c-myc gene activation was found in 100% and 70% of tumours containing mutation and deletion respectively. This suggests that the two proto-oncogenes cooperate for the progression of cervical cancers. Furthermore as more than 90% of these tumours contained also human papillomavirus sequences, our data strongly suggest that multiple genetic events are involved in the genesis and progression of most cervical cancers.
对宫颈癌中的c-Ha-ras-1基因座进行了分析，结果显示，在36%的杂合性肿瘤中存在一个等位基因缺失，在24%的晚期肿瘤中密码子12处发生了突变。40%发生突变的肿瘤还存在缺失。在分别含有突变和缺失的肿瘤中，c-myc基因激活的发现率分别为100%和70%。这表明这两个原癌基因在宫颈癌进展过程中相互协作。此外，由于这些肿瘤中超过90%还含有人类乳头瘤病毒序列，我们的数据强烈表明，大多数宫颈癌的发生和进展涉及多个基因事件。
