Tahara Nobuhiro, Yamagishi Sho-Ichi, Kodama Norihiro, Tahara Atsuko, Honda Akihiro, Nitta Yoshikazu, Igata Sachiyo, Matsui Takanori, Takeuchi Masayoshi, Kaida Hayato, Kurata Seiji, Abe Toshi, Fukumoto Yoshihiro
Department of Medicine, Division of Cardiovascular Medicine (N.T., N.K., A.T., A.H., Y.N., S.I., Y.F.), and Departments of Radiology (H.K., S.K., T.A.) and Pathophysiology and Therapeutics of Diabetic Vascular Complications (T.M., S.-Y.), Kurume University School of Medicine, Kurume 830-0011, Japan; and Department of Advanced Medicine (M.T.), Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0293, Japan.
J Clin Endocrinol Metab. 2015 May;100(5):E739-47. doi: 10.1210/jc.2014-3896. Epub 2015 Feb 19.
Body fat distribution and inflammation may play a role in metabolic derangements and cardiovascular disease in obesity.
The aim of this study is to investigate clinical and biochemical factors associated with area and metabolic activity in the visceral and subcutaneous adipose tissues (VAT and SAT).
(18)F-fluorodeoxyglucose-positron emission tomography and computed tomography imaging was performed in 251 consecutive subjects (62.6 ± 9.3 y) for risk screening.
We examined which clinical, anthropometric, metabolic, and inflammatory variables including advanced glycation end products (AGEs) and pigment epithelium-derived factor (PEDF) were independently associated with area and metabolic activity in VAT and SAT. Adipose tissue area was determined with computed tomography, whereas metabolic activity was assessed by (18)F-fluorodeoxyglucose uptake expressed as a target to background ratio (TBR) of blood-normalized standardized uptake.
Serum levels of AGEs and PEDF were 9.81 ± 3.21 U/mL and 14.0 (range 10.8-17.7) μg/mL, respectively. Although the area in VAT and SAT was associated with waist circumference and sex, each adipose tissue area and TBR had different metabolic risk profiles. The TBR value in VAT was higher than that in SAT. In a multiple stepwise regression analysis, AGEs and medication for hypertension were independently associated with VAT TBR (R(2) = 0.102), whereas medication for diabetes, mean intima-media thickness, AGEs, and PEDF were the independent correlates of SAT TBR (R(2) = 0.132).
The present study demonstrated that area and metabolic activity in VAT and SAT could be differently regulated, suggesting the involvement of AGEs and PEDF in adipose tissue inflammation.
体脂分布和炎症可能在肥胖相关的代谢紊乱和心血管疾病中起作用。
本研究旨在调查与内脏和皮下脂肪组织（VAT和SAT）的面积及代谢活性相关的临床和生化因素。
对251名连续受试者（62.6±9.3岁）进行了（18）F-氟脱氧葡萄糖-正电子发射断层扫描和计算机断层扫描成像以进行风险筛查。
我们检查了哪些临床、人体测量、代谢和炎症变量，包括晚期糖基化终产物（AGEs）和色素上皮衍生因子（PEDF），与VAT和SAT的面积及代谢活性独立相关。通过计算机断层扫描确定脂肪组织面积，而代谢活性通过以血液标准化标准化摄取值的靶本比（TBR）表示的（18）F-氟脱氧葡萄糖摄取来评估。
AGEs和PEDF的血清水平分别为9.81±3.21 U/mL和14.0（范围10.8 - 17.7）μg/mL。虽然VAT和SAT的面积与腰围和性别相关，但每个脂肪组织面积和TBR都有不同的代谢风险特征。VAT中的TBR值高于SAT中的TBR值。在多元逐步回归分析中，AGEs和高血压药物治疗与VAT TBR独立相关（R（2）= 0.102），而糖尿病药物治疗、平均内膜中层厚度、AGEs和PEDF是SAT TBR的独立相关因素（R（2）= 0.132）。
本研究表明，VAT和SAT的面积及代谢活性可能受到不同调节，提示AGEs和PEDF参与脂肪组织炎症。
