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左乳内动脉心肌血运重建术后血胸行胸膜腔内链激酶治疗后发生严重出血。

Severe haemorrhage following intrapleural streptokinase therapy for haemothorax after myocardial revascularisation with the left internal mammary artery.

作者信息

Winter J B, Zijlstra J G, van der Werf T S

出版信息

Neth Heart J. 2002 Oct;10(10):419-421.

PMID:25696038
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2499785/
Abstract

Administration of intrapleural streptokinase is a well-accepted therapy for the treatment of haemothorax following myocardial revascularisation with the inner mammary artery (IMA). The present report describes a patient who developed severe hypotension with an accompanying drop in haemoglobin concentration induced by the sixth consecutive instillation of intrapleural streptokinase. This case suggests that the standard streptokinase therapy of six to eight instillations might be too much for these patients.

摘要

胸腔内注射链激酶是一种广泛认可的治疗方法,用于治疗采用乳内动脉(IMA)进行心肌血运重建术后的血胸。本报告描述了一名患者,在连续第六次胸腔内注射链激酶后出现严重低血压,并伴有血红蛋白浓度下降。该病例表明,对于这些患者而言,标准的六至八次注射链激酶治疗可能剂量过大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c7d/2499785/e994623f9bd2/Nheartj00133-0036-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c7d/2499785/2461ba56afdd/Nheartj00133-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c7d/2499785/cbb150104125/Nheartj00133-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c7d/2499785/e994623f9bd2/Nheartj00133-0036-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c7d/2499785/2461ba56afdd/Nheartj00133-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c7d/2499785/cbb150104125/Nheartj00133-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c7d/2499785/e994623f9bd2/Nheartj00133-0036-c.jpg

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1
Severe haemorrhage following intrapleural streptokinase therapy for haemothorax after myocardial revascularisation with the left internal mammary artery.左乳内动脉心肌血运重建术后血胸行胸膜腔内链激酶治疗后发生严重出血。
Neth Heart J. 2002 Oct;10(10):419-421.
2
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本文引用的文献

1
THE EFFECT IN PATIENTS OF STREPTOCOCCAL FIBRINOLYSIN (STREPTOKINASE) AND STREPTOCOCCAL DESOXYRIBONUCLEASE ON FIBRINOUS, PURULENT, AND SANGUINOUS PLEURAL EXUDATIONS.链球菌纤维蛋白溶酶(链激酶)和链球菌脱氧核糖核酸酶对患者纤维蛋白性、脓性和血性胸腔渗出液的作用
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2
[Treatment with intrapleural streptokinase for coagulated hemothorax after cardiac surgery with cardiopulmonary bypass].[体外循环心脏手术后凝固性血胸的胸膜腔内链激酶治疗]
Rev Esp Cardiol. 2001 Mar;54(3):294-8. doi: 10.1016/s0300-8932(01)76311-7.
3
The systemic fibrinolytic activity of intrapleural streptokinase.
胸腔内链激酶的全身纤维蛋白溶解活性。
Am J Respir Crit Care Med. 1998 Jan;157(1):328-30. doi: 10.1164/ajrccm.157.1.97-03094.
4
Exclusive use of arterial grafts in coronary artery bypass operations for three-vessel disease: use of both thoracic arteries and the gastroepiploic artery in 256 consecutive patients.在三支血管病变的冠状动脉搭桥手术中单纯使用动脉移植物:256例连续患者使用胸廓内动脉和胃网膜动脉的情况。
J Thorac Cardiovasc Surg. 1996 Oct;112(4):935-42. doi: 10.1016/s0022-5223(96)70093-4.
5
Intrapleural streptokinase in the management of empyema.胸膜腔内注射链激酶治疗脓胸
Thorax. 1994 Sep;49(9):856-9. doi: 10.1136/thx.49.9.856.
6
Role of streptokinase in the treatment of acute loculated parapneumonic pleural effusions and empyema.链激酶在急性包裹性肺炎旁胸腔积液和脓胸治疗中的作用。
Thorax. 1994 Sep;49(9):852-5. doi: 10.1136/thx.49.9.852.
7
Major hemorrhage following administration of intrapleural streptokinase.胸腔内注射链激酶后发生大出血。
Chest. 1984 Sep;86(3):486-7. doi: 10.1378/chest.86.3.486.
8
Use of purified streptokinase in empyema and hemothorax.纯化链激酶在脓胸和血胸治疗中的应用。
Am J Surg. 1991 May;161(5):560-2. doi: 10.1016/0002-9610(91)90899-o.
9
Intrapleural streptokinase in the treatment of haemothorax and empyema.胸腔内注射链激酶治疗血胸和脓胸。
Scand J Thorac Cardiovasc Surg. 1977;11(3):265-8.