Meuwissen M, van der Wal A C, Siebes M, Koch K T, Chamuleau S A J, van der Loos C M, Teeling P, de Winter R J, Niessen H W M, Tijssen J G P, Becker A E, Piek J J
Neth Heart J. 2004 Mar;12(3):106-109.
Inflammation plays an important role in the initiation, development, progression and complications of atherosclerotic vascular disease. Our present knowledge of the elementary role of inflammation for the onset of plaque rupture in atherosclerotic coronary lesions primarily stems from autopsy studies. However, the introduction of directional coronary atherectomy catheters has provided a unique opportunity to directly investigate the role of inflammation in coronary syndromes. In this report we describe the role of coronary plaque inflammation, as determined by immunohistochemistry, on the presentation of coronary syndromes and on the clinical outcome following percutaneous interventions.
炎症在动脉粥样硬化性血管疾病的起始、发展、进程及并发症中起着重要作用。我们目前对于炎症在动脉粥样硬化性冠状动脉病变中斑块破裂起始的基本作用的认识主要源于尸检研究。然而，定向冠状动脉旋切导管的引入提供了一个直接研究炎症在冠状动脉综合征中作用的独特机会。在本报告中，我们描述了通过免疫组织化学确定的冠状动脉斑块炎症在冠状动脉综合征表现及经皮介入治疗后临床结局中的作用。
