Boczar Kevin E, Liu Peter, Chong Aun Yeong, So Derek, Dowlatshahi Dar, Rayner Katey, Beanlands Rob
Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
CJC Open. 2020 Dec 31;3(5):675-679. doi: 10.1016/j.cjco.2020.12.020. eCollection 2021 May.
We identified the prevalence of elevated high-sensitivity C-reactive protein and interleukin-6 in patients with recent cardiovascular (CV) events with or without prediabetes/diabetes, and in a control group of patients with remote CV events. Interleukin-6 was elevated in patients with prediabetes/diabetes and recent CV events (median, 4.84 pg/mL; interquartile range, 3.27-7.45) compared with patients with remote events (2.36 pg/mL; interquartile range, 1.09-4.00). There was a trend for elevated high-sensitivity C-reactive protein in patients with acute events and prediabetes/diabetes ( = 0.147). This supports the notion that patients with prediabetes/diabetes and recent CV events have higher inflammatory burdens than patients without recent CV events or dysglycemia.
我们确定了近期发生心血管（CV）事件的患者（无论有无糖尿病前期/糖尿病）以及有既往CV事件的对照组患者中高敏C反应蛋白和白细胞介素-6升高的患病率。与有既往CV事件的患者（中位数为2.36 pg/mL；四分位间距为1.09 - 4.00）相比，糖尿病前期/糖尿病且近期发生CV事件的患者白细胞介素-6升高（中位数为4.84 pg/mL；四分位间距为3.27 - 7.45）。急性事件且患有糖尿病前期/糖尿病的患者中高敏C反应蛋白有升高趋势（P = 0.147）。这支持了这样一种观点，即糖尿病前期/糖尿病且近期发生CV事件的患者比无近期CV事件或血糖异常的患者有更高的炎症负担。
