Helgason C D, Wood J D
Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada.
Neurochem Res. 1989 Apr;14(4):297-300. doi: 10.1007/BF01000030.
Changes in the amounts of proteins and amino acids in synaptosomes and whole tissue from the olfactory bulb and cerebral cortex of rats were measured during the period 5-25 days postnatal. The amount of neurotransmitter type amino acids (such as GABA, glutamate and aspartate) associated with synaptosomes obtained from 1g of brain tissue increased dramatically with the age of the animals, whereas non-transmitter type amino acids (such as serine and glutamine) showed relatively little change. The results were in harmony with an earlier cessation of synaptogenesis in the olfactory bulb than in the cerebral cortex.
在出生后5至25天期间，对大鼠嗅球和大脑皮层的突触体及全组织中的蛋白质和氨基酸含量变化进行了测量。从1克脑组织中获得的与突触体相关的神经递质型氨基酸（如γ-氨基丁酸、谷氨酸和天冬氨酸）的含量随着动物年龄的增长而急剧增加，而非递质型氨基酸（如丝氨酸和谷氨酰胺）的变化相对较小。结果与嗅球中突触发生比大脑皮层更早停止的情况一致。
