Godfrey D A, Ross C D, Carter J A, Lowry O H, Matschinsky F M
J Histochem Cytochem. 1980 Nov;28(11):1157-69. doi: 10.1177/28.11.7430613.
Levels of the proposed neurotransmitter amino acids glutamate, aspartate, gamma-aminobutyric acid (GABA), and glycine were measured within the layered structures of the olfactory bulb and olfactory cortex following unilateral transections of the lateral olfactory tract or of virtually all fiber tracts of the olfactory peduncle. Distributions of the amino acids on both lesion and control sides were examined and compared by means of a mapping procedure. The results suggest: 1) Glutamate and aspartate are specifically associated with mitral (and presumably also tufted) cell axons and terminals in the piriform cortex. The distribution of aspartate in the olfactory bulb is further suggestive of a specific association of aspartate with mitral cell dendrites and somata. 2) Glutamate might be specifically associated with some centrifugal fibers traveling to the olfactory bulb in or near the anterior commissure. 3) GABA might be specifically related to some certrifugal fibers to the olfactory bulb in addition to its prominent association with granule cells of the bulb. 4) Glycine is unlikely to play a prominent neurotransmitter role in either the olfactory bulb or olfactory cortex.
在单侧横断外侧嗅束或嗅球柄几乎所有纤维束之后，对嗅球和嗅皮质分层结构内的谷氨酸、天冬氨酸、γ-氨基丁酸（GABA）和甘氨酸等拟议神经递质氨基酸水平进行了测量。通过一种绘图程序检查并比较了损伤侧和对照侧氨基酸的分布情况。结果表明：1）谷氨酸和天冬氨酸与梨状皮质中的二尖瓣（可能还有簇状）细胞轴突和终末有特异性关联。天冬氨酸在嗅球中的分布进一步提示天冬氨酸与二尖瓣细胞树突和胞体有特异性关联。2）谷氨酸可能与一些在前连合内或其附近向嗅球行进的离心纤维有特异性关联。3）GABA除了与嗅球颗粒细胞有显著关联外，可能还与一些向嗅球的离心纤维有特异性关系。4）甘氨酸在嗅球或嗅皮质中不太可能发挥突出的神经递质作用。
