β受体阻滞剂治疗神经心源性功能障碍的临床研究结果
Beta blockade in neurocardiogenic dysfunction: results of a clinical study.
作者信息
Baselier M R P, van den Bos A A
出版信息
Neth Heart J. 2001 Oct;9(7):275-278.
BACKGROUND
Few placebo-controlled studies with β-blockers have been performed in patients suffering from neurocardiogenic syncope.
METHODS
We investigated the efficacy of metoprolol in 26 patients with recurrent syncope, suspected to be of neurocardiogenic origin, and positive tilt table test (TTT) outcome in a single-centre, double-blind, placebo-controlled, crossover study, with treatment periods of two weeks. Therapeutic efficacy was defined as a negative TTT after metoprolol and a positive TTT after placebo. Therapeutic failure was defined as a positive TTT after metoprolol and a positive or negative TTT after placebo. Patients with a negative TTT test after both metoprolol and placebo comprised the third group.
RESULTS
The 24 patients who completed the study consisted of 14 females and 10 males, mean age 53 years, range 18-75 years. Therapeutic efficacy was observed in nine patients, therapeutic failure in eight patients and seven patients had a negative TTT after both placebo and metoprolol. According to the exact binomial test for paired proportions, the 95% confidence interval is 12 to 38% and p<0.01 in favour of treatment with metoprolol.
CONCLUSION
These findings indicate a favourable effect of metoprolol.
背景
针对患有神经心源性晕厥的患者，很少有使用β受体阻滞剂的安慰剂对照研究。
方法
在一项单中心、双盲、安慰剂对照、交叉研究中，我们调查了美托洛尔对26例复发性晕厥患者的疗效，这些患者疑似神经心源性晕厥且倾斜试验（TTT）结果呈阳性，治疗期为两周。治疗效果定义为服用美托洛尔后TTT为阴性，服用安慰剂后TTT为阳性。治疗失败定义为服用美托洛尔后TTT为阳性，服用安慰剂后TTT为阳性或阴性。美托洛尔和安慰剂后TTT试验均为阴性的患者构成第三组。
结果
完成研究的24例患者包括14名女性和10名男性，平均年龄53岁，范围为18 - 75岁。9例患者观察到治疗效果，8例患者治疗失败，7例患者在服用安慰剂和美托洛尔后TTT均为阴性。根据配对比例的确切二项式检验，95%置信区间为12%至38%，p<0.01，支持美托洛尔治疗。
结论
这些发现表明美托洛尔有良好效果。
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