Sorokina I V, Baev D S, Zhukova N A, Tolstikova T G, Antimonova A N, Petrenko N I, Shul'ts E E, Grigor'ev I A
Bioorg Khim. 2013 Nov-Dec;39(6):749-52. doi: 10.1134/s1068162013060083.
Betulonic acid amides containing a nitroxyl radical moiety possess antiholestatic effects in mice. Introduction ofpiperidine nitroxide moiety into lupan core increases its hepatoprotective activity. Oral administration of piperidine nitroxide derivative in dose 50 mg/kg doesn't stimulate transplanted tumor growth and raises a lifespan of mice.
含有硝酰基部分的桦木酸酰胺在小鼠中具有抗胆汁淤积作用。将哌啶氮氧化物部分引入羽扇豆核心可增强其肝脏保护活性。以50mg/kg的剂量口服哌啶氮氧化物衍生物不会刺激移植肿瘤的生长，并可延长小鼠的寿命。
