Malviya Rishabha, Sharma Pramod K
Polim Med. 2014 Jul-Sep;44(3):141-6.
Natural polymers have been used as pharmaceutical excipients. They are easily available, cheap, less toxic andbiodegradable. Many of them have been identified and research is ongoing regarding their characterization.
The present study depicts the extraction and characterization of Aegle marmelos derived polymer which can be used as a pharmaceutical excipient.
A water based extraction method was used to extract Aegle marmelos derived polymer. Its yield was found to be 15.07%. Characterization was based on various parameters such as a test for carbohydrates, test for purity, organoleptic properties, ash value, solubility behavior, pH, swelling index, surface tension, viscosity, particle size, loss on drying, bulk density, bulkiness, powder flow behavior, etc.
The polymer was yellowish-brown and showed poor flow (angle of repose 19.28 degrees ± 0.883) with neutral pH, i.e. 7, and bulkiness depicting the heaviness of polymer. The extracted polymer showed solubility in warm water and insolubility in organic solvents.
The results easily predict the fact that the yield of the polymer was quite good, so it can be used as a commercial source of mucilage. The isolated polymer can be used as a pharmaceutical excipient in different dosage forms. 2 /
天然聚合物已被用作药物赋形剂。它们易于获得、价格低廉、毒性较小且可生物降解。其中许多已被鉴定出来，并且关于它们的表征的研究正在进行中。
本研究描述了可作为药物赋形剂的枸橼酸聚合物的提取和表征。
采用水基提取法提取枸橼酸聚合物。其产率为15.07%。表征基于各种参数，如碳水化合物测试、纯度测试、感官特性、灰分值、溶解性、pH值、膨胀指数、表面张力、粘度、粒径、干燥失重、堆密度、松密度、粉末流动行为等。
该聚合物为黄褐色，流动性差（休止角为19.28度±0.883），pH值呈中性，即7，松密度表明聚合物较重。提取的聚合物在温水中可溶，在有机溶剂中不溶。
结果很容易预测聚合物的产率相当高这一事实，因此它可以用作商业胶浆来源。分离出的聚合物可作为不同剂型的药物赋形剂。 2 /
