Alonso Joaquín J, Muñiz Javier, Gómez-Doblas Juan José, Rodríguez-Roca Gustavo, Lobos José María, Permanyer-Miralda Gaietà, Anguita Manuel, Chorro Francisco Javier, Roig Eulàlia
Servicio de Cardiología, Hospital Universitario de Getafe, Getafe, Madrid, Spain.
Instituto de Ciencias de la Salud, Universidad de A Coruña, INIBIC, A Coruña, Spain.
Rev Esp Cardiol (Engl Ed). 2015 Aug;68(8):691-9. doi: 10.1016/j.rec.2014.09.020. Epub 2015 Feb 17.
The objective of the OFRECE study was to estimate the prevalence of stable angina in Spain. This prevalence is currently unknown, due to a lack of recent studies and to changes in the epidemiology and treatment of ischemic heart disease.
This cross-sectional study involved a representative sample of the Spanish population aged 40 years or older, obtained via 2-stage random sampling: in the first stage, primary care physicians were randomly selected from each Spanish province, whereas in the second stage 20 people were selected from the population assigned to each physician. The prevalence was weighted by age, sex, and geographical area. Participants were classified as having angina if they met the "definite angina" criteria of the Rose questionnaire and as having confirmed angina if the angina was confirmed by a cardiologist or if they had a history of acute ischemic heart disease or revascularization.
Of the 11 831 people invited to participate, 8378 (71%) were analyzed (mean age, 59.2 years). The weighted prevalence of definite angina (Rose) was 2.6% (95% confidence interval, 2.1%-3.1%) and was higher in women (2.9%) than in men (2.2%), whereas that of confirmed angina was 1.4% (95% confidence interval, 1.0%-1.8%), without differences between men (1.5%) and women (1.3%). The prevalence of definite angina (Rose) increased with age (0.7% in patients aged 40 to 49 years and 7.1% in those aged 70 years or older), history of cardiovascular disease, and cardiovascular risk factors, except smoking.
The prevalence of definite angina (Rose) in the Spanish population aged 40 years or older was 2.6%, whereas that of confirmed angina was 1.4%. Both prevalences increased with age, cardiovascular risk factors, and cardiovascular history.
OFRECE研究的目的是评估西班牙稳定型心绞痛的患病率。由于缺乏近期研究以及缺血性心脏病的流行病学和治疗方法的变化，目前尚不清楚该患病率。
这项横断面研究涉及通过两阶段随机抽样获得的40岁及以上西班牙人群的代表性样本：在第一阶段，从西班牙每个省份随机选择初级保健医生，而在第二阶段，从分配给每位医生的人群中选择20人。患病率按年龄、性别和地理区域加权。如果参与者符合罗斯问卷的“明确心绞痛”标准，则被分类为患有心绞痛；如果心绞痛得到心脏病专家的确认，或者他们有急性缺血性心脏病或血运重建病史，则被分类为患有确诊心绞痛。
在受邀参与的11831人中，8378人（71%）接受了分析（平均年龄59.2岁）。明确心绞痛（罗斯标准）的加权患病率为2.6%（95%置信区间，2.1%-3.1%），女性（2.9%）高于男性（2.2%），而确诊心绞痛的患病率为1.4%（95%置信区间，1.0%-1.8%），男性（1.5%）和女性（1.3%）之间无差异。明确心绞痛（罗斯标准）的患病率随年龄（40至49岁患者中为0.7%，70岁及以上患者中为7.1%）、心血管疾病史和心血管危险因素（吸烟除外）而增加。
40岁及以上西班牙人群中明确心绞痛（罗斯标准）的患病率为2.6%，而确诊心绞痛的患病率为1.4%。这两种患病率均随年龄、心血管危险因素和心血管病史而增加。
