探讨多发性硬化症中灰质损伤的起源。

Exploring the origins of grey matter damage in multiple sclerosis.

机构信息

Advanced Neuroimaging Laboratory of Neurology B, Department of Neurological and Movement Sciences, University Hospital Verona, Piazzale Ludovico Antonio Scuro 10, 37134, Verona, Italy.

1] Division of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK. [2] Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.

出版信息

Nat Rev Neurosci. 2015 Mar;16(3):147-58. doi: 10.1038/nrn3900.

DOI:10.1038/nrn3900

PMID:25697158

Abstract

Multiple sclerosis is characterized at the gross pathological level by the presence of widespread focal demyelinating lesions of the myelin-rich white matter. However, it is becoming clear that grey matter is not spared, even during the earliest phases of the disease. Furthermore, grey matter damage may have an important role both in physical and cognitive disability. Grey matter pathology involves both inflammatory and neurodegenerative mechanisms, but the relationship between the two is unclear. Histological, immunological and neuroimaging studies have provided new insight in this rapidly expanding field, and form the basis of the most recent hypotheses on the pathogenesis of grey matter damage.

摘要

多发性硬化症在大体病理水平上的特征是广泛存在富含髓磷脂的白质局灶性脱髓鞘病变。然而，即使在疾病的早期阶段，也越来越清楚地表明灰质并未幸免。此外，灰质损伤在身体和认知障碍中可能都具有重要作用。灰质病变涉及炎症和神经退行性机制，但两者之间的关系尚不清楚。组织学、免疫学和神经影像学研究为这一迅速发展的领域提供了新的见解，并为灰质损伤发病机制的最新假说提供了依据。