Koster Remco A, Alffenaar Jan-Willem C, Botma Rixt, Greijdanus Ben, Touw Daan J, Uges Donald R A, Kosterink Jos G W
Laboratory for Clinical & Forensic Toxicology & Drugs Analysis, Department of Clinical Pharmacy & Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
Bioanalysis. 2015;7(3):345-51. doi: 10.4155/bio.14.298.
Remco Koster is a research analyst and PhD candidate at the University Medical Center Groningen and University of Groningen. He has been working in the field of bioanalysis for over 13 years, where he has developed numerous analytical methods using LC-MS/MS. His main research focus is the influence of various matrices on the development and performance of analytical methods using LC-MS/MS. The development of high-speed extraction and analysis methods for drugs and drugs of abuse in human matrices like blood, plasma, hair, saliva and dried blood spots often leads to improved procedures for preparation of standards and quality control samples, sample handling and validation. Two hematocrit preparation procedures for standards and quality control samples were evaluated in order to improve the quality of procedures for dried blood spot validation and analysis.
雷姆科·科斯特是格罗宁根大学医学中心和格罗宁根大学的研究分析师及博士研究生。他在生物分析领域工作了13年多，在此期间开发了众多使用液相色谱 - 串联质谱法（LC-MS/MS）的分析方法。他的主要研究重点是各种基质对使用LC-MS/MS的分析方法的开发和性能的影响。在血液、血浆、毛发、唾液和干血斑等人体基质中开发药物和滥用药物的高速提取和分析方法，通常会改进标准品和质量控制样品的制备程序、样品处理及验证。为了提高干血斑验证和分析程序的质量，对标准品和质量控制样品的两种血细胞比容制备程序进行了评估。
