[Role of adrenoreceptors in the activation of the mouse hypothalamo-pituitary testicular complex induced by the presence of a female].

A study was made of the role of the adrenergic mechanisms in the activation of endocrine testicular function of CBA/Lac and A/He male mice induced by the presence of a female in estrus without any tactile contact with a male. The alpha 1-adrenoreceptor blocker prazosin inhibited completely an increase in the peripheral blood plasma testosterone level caused by the receptive female challenge. At the same time, optimol blockade of beta 2-adrenoreceptors markedly increased the stimulating effect of the receptive female presence on the blood testosterone level. The expression of optimol action on the blood testosterone level depended on a male genotype. A conclusion was made that during sexual motivation in male mice caused by the presence of a receptive female, the stimulatory effects on testicular endocrine function were produced through the alpha 1-adrenoreceptors and the inhibitory effects were produced through the beta 2-adrenoreceptors.