Hu Chi, Zheng Yu, Yu Ziyi, Abell Chris, Scherman Oren A
Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Chem Commun (Camb). 2015 Mar 21;51(23):4858-60. doi: 10.1039/c5cc00121h.
The fabrication, characterisation and controlled burst release of naphthol-functionalised micellar (NFM) nanostructures, which were grafted onto gold surfaces through cucurbit[8]uril (CB[8]) mediated host-guest interactions are described. NFMs undergo a facile change in morphology from micelles to diblock copolymers in direct response to exposure to organic solvents, including tetrahydrofuran (THF), toluene and chloroform. This induced transition in conformation lends itself to potential applications including nanocarriers for triggered burst-release of guest molecules. Nile Red was investigated as a NFM encapsulated model hydrophobic cargo inside the surface-attached micelles, which could be fully released upon exposure to THF as measured by both atomic force microscopy and UV/vis spectroscopy.
本文描述了通过葫芦[8]脲（CB[8]）介导的主客体相互作用接枝到金表面的萘酚功能化胶束（NFM）纳米结构的制备、表征及可控突释。NFM在暴露于包括四氢呋喃（THF）、甲苯和氯仿在内的有机溶剂时，会直接从胶束形态轻松转变为二嵌段共聚物。这种诱导的构象转变使其具有潜在应用，包括用于触发客体分子突释的纳米载体。尼罗红作为一种被封装在表面附着胶束内的NFM模型疏水性货物进行了研究，通过原子力显微镜和紫外/可见光谱测量，其在暴露于THF时可完全释放。
