口腔和皮肤鳞状细胞癌中的基质金属蛋白酶-7、基质金属蛋白酶-8和基质金属蛋白酶-9
MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas.
作者信息
Ahmed Haji Omar Abdirisak, Haglund Caj, Virolainen Susanna, Häyry Valtteri, Atula Timo, Kontio Risto, Salo Tuula, Sorsa Timo, Hagström Jaana
机构信息
Institute of Dentistry, University of Helsinki, Helsinki, Finland.
Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland; Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Apr;119(4):459-67. doi: 10.1016/j.oooo.2014.12.019. Epub 2015 Jan 6.
OBJECTIVES
Oral squamous cell carcinoma (OSCC) and cutaneous squamous cell carcinoma (CSCC) are epithelial neoplasms, of which OSCC has a worse prognosis. Matrix metalloproteinases (MMPs) are involved in the initiation, invasion, metastasis, and defense of cancer. This study aimed to compare differences in MMP expression in these cancers.
STUDY DESIGN
Sixty-one patients with early-stage (T1-T2 N0 M0) cancers, of which 36 were OSCC and 25 CSCC, were enrolled into this study. Immunohistochemical staining was performed with MMP-7, MMP-8, and MMP-9 antibodies.
RESULTS
MMP-7 expression was stronger in OSCC than in CSCC, mainly in the invasive front. MMP-8 was absent and MMP-9 was mildly expressed in OSCC and CSCC cells. However, MMP-8 and MMP-9 were positive in peritumoral inflammatory cells in both cancers. In addition, MMP-7, MMP-8, and MMP-9 were not associated with the overall survival of patients with OSCC and CSCC patients.
CONCLUSIONS
The increased expression of MMP-7 in the invasive front may partly explain the aggressiveness of OSCC.
目的
口腔鳞状细胞癌（OSCC）和皮肤鳞状细胞癌（CSCC）均为上皮性肿瘤，其中OSCC的预后更差。基质金属蛋白酶（MMPs）参与癌症的发生、侵袭、转移及防御过程。本研究旨在比较这些癌症中MMP表达的差异。
研究设计
61例早期（T1-T2 N0 M0）癌症患者纳入本研究，其中36例为OSCC，25例为CSCC。采用MMP-7、MMP-8和MMP-9抗体进行免疫组织化学染色。
结果
MMP-7在OSCC中的表达强于CSCC，主要位于侵袭前沿。MMP-8在OSCC和CSCC细胞中均无表达，MMP-9呈轻度表达。然而，MMP-8和MMP-9在两种癌症的瘤周炎性细胞中均呈阳性。此外，MMP-7、MMP-8和MMP-9与OSCC和CSCC患者的总生存期无关。
结论
侵袭前沿MMP-7表达增加可能部分解释了OSCC的侵袭性。
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