Otting U, Hellmann C, Gellert S, Devaux S, Grossmann P
Klinik und Poliklinik für Kinderheilkunde Bereiches Medizin (Charité) Humboldt-Universität zu Berlin.
Z Urol Nephrol. 1989 Jun;82(6):331-8.
Liver enzymes were measured in 24 children with different degrees of renal insufficiency, in 6 children treated by chronic hemodialysis and in 13 children after kidney transplantation. The hemodialyzed and transplanted patients have the highest ALAT activity, independently of the presence of a liver infection. The AP activity in these patient groups were not different from the reference value. The activity of ALAT, GGT and CHE, respectively were most pathologic in the hemodialysis group. The enzyme activities have not been influenced by a single dialysis and a 6-month dialysis course. In uremic and chronic hemodialyzed patients the enzyme combination of ALAT, GGT and CHE has been recommended in the diagnosis and follow-up control of a liver cell damage. In the evaluation of enzyme activities in comparison with reference values of healthy volunteers an enzyme inhibition by the uremic serum should considered.
对24名不同程度肾功能不全的儿童、6名接受慢性血液透析治疗的儿童以及13名肾移植后的儿童进行了肝酶检测。接受血液透析和移植的患者谷丙转氨酶（ALAT）活性最高，与是否存在肝脏感染无关。这些患者组的碱性磷酸酶（AP）活性与参考值无差异。血液透析组中，谷丙转氨酶、γ-谷氨酰转肽酶（GGT）和胆碱酯酶（CHE）的活性分别最具病理学意义。酶活性不受单次透析和6个月透析疗程的影响。对于尿毒症和慢性血液透析患者，推荐将谷丙转氨酶、γ-谷氨酰转肽酶和胆碱酯酶联合用于肝细胞损伤的诊断和随访监测。在与健康志愿者参考值比较评估酶活性时，应考虑尿毒症血清对酶的抑制作用。
