去甲激肽对组织培养及小鼠体内呼吸道合胞病毒的影响。

Effects of norakin on respiratory syncytial virus in tissue culture and in mice.

作者信息

Mentel R, Schroeder C, Döhner L

机构信息

Institut für Medizinische Mikrobiologie, Ernst-Moritz-Arndt-Universität, Greifswald, DDR.

出版信息

Acta Virol. 1989 Mar;33(2):162-6.

PMID:2569812

Abstract

Norakin at 1 microgram/ml inhibits the reproduction of respiratory syncytial virus (RSV) in Vero cells to 50% and at 5 micrograms/ml to 90%. The development of lung lesions in RSV-infected BALB/c mice was suppressed by 70% when the animals were treated with two doses (25 mg/kg each) of norakin, 30 min before and 4 hr post infection. (p.i.), respectively.

摘要

诺拉金在浓度为1微克/毫升时可将呼吸道合胞病毒（RSV）在Vero细胞中的繁殖抑制50%，在浓度为5微克/毫升时可抑制90%。在用两剂诺拉金（每次25毫克/千克）分别在感染前30分钟和感染后4小时对感染RSV的BALB/c小鼠进行处理后，肺部病变的发展受到了70%的抑制。