诱导坏死性凋亡的铼（V）氧配合物
Necroptosis-inducing rhenium(V) oxo complexes.
作者信息
Suntharalingam Kogularamanan, Awuah Samuel G, Bruno Peter M, Johnstone Timothy C, Wang Fang, Lin Wei, Zheng Yao-Rong, Page Julia E, Hemann Michael T, Lippard Stephen J
机构信息
Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
出版信息
J Am Chem Soc. 2015 Mar 4;137(8):2967-74. doi: 10.1021/ja511978y. Epub 2015 Feb 20.
Abstract
Rhenium(V) oxo complexes of general formula [ReO(OMe)(N^N)Cl2], where N^N = 4,7-diphenyl-1,10-phenanthroline, 1, or 3,4,7,8-tetramethyl-1,10-phenanthroline, 2, effectively kill cancer cells by triggering necroptosis, a non-apoptotic form of cell death. Both complexes evoke necrosome (RIP1-RIP3)-dependent intracellular reactive oxygen species (ROS) production and propidium iodide uptake. The complexes also induce mitochondrial membrane potential depletion, a possible downstream effect of ROS production. Apparently, 1 and 2 are the first rhenium complexes to evoke cellular events consistent with programmed necrosis in cancer cells. Furthermore, 1 and 2 display low acute toxicity in C57BL/6 mice and reasonable stability in fresh human blood.
摘要
通式为[ReO(OMe)(N^N)Cl2]的铼（V）氧代配合物，其中N^N = 4,7 - 二苯基 - 1,10 - 菲咯啉（1）或3,4,7,8 - 四甲基 - 1,10 - 菲咯啉（2），通过引发坏死性凋亡（一种非凋亡形式的细胞死亡）有效杀死癌细胞。两种配合物均引发依赖坏死小体（RIP1 - RIP3）的细胞内活性氧（ROS）生成和碘化丙啶摄取。这些配合物还诱导线粒体膜电位耗竭，这可能是ROS生成的下游效应。显然，1和2是首批引发与癌细胞程序性坏死一致的细胞事件的铼配合物。此外，1和2在C57BL / 6小鼠中显示出低急性毒性，并且在新鲜人血中具有合理的稳定性。
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