具有可见光诱导抗癌活性的铼配合物。
Rhenium complexes with visible-light-induced anticancer activity.
机构信息
Fachbereich Chemie, Philipps-Universität Marburg, Marburg, Germany.
出版信息
ChemMedChem. 2013 Jun;8(6):924-7. doi: 10.1002/cmdc.201300060. Epub 2013 Apr 8.
Abstract
Shedding light on the matter: Rhenium(I) indolato complexes with highly potent visible-light-triggered antiproliferative activity (complex 1: EC50 light=0.1 μM vs EC50 dark=100 μM) in 2D- and 3D-organized cancer cells are reported and can be traced back to an efficient generation of singlet oxygen, causing rapid morphological changes and an induction of apoptosis.
摘要
阐明问题
报道了铼（I）吲哚配合物具有高效的可见光触发的抗增殖活性（配合物 1：EC50 light=0.1 μM 对 EC50 dark=100 μM），在 2D 和 3D 组织的癌细胞中，这可以追溯到单线态氧的有效产生，导致快速的形态变化和诱导细胞凋亡。
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2
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3
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4
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5
Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes.作为生物分子和细胞探针的发光无机和有机过渡金属配合物的应用。
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6
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7
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8
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9
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10
Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine.光动力化疗（PACT）：激发态 d 区金属在医学中的潜力。
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