Hafner S, Wiesner H, von Hegel G, Halm S, Erhardt W
Berl Munch Tierarztl Wochenschr. 1989 Jun 1;102(6):181-4.
The ability of the antagonists tolazoline, yohimbine and the combination of yohimbine with 4-aminopyridine to reverse the effects of the xylazine-component of the "Hellabrunn mixture" (125 mg/ml xylazine and 100 mg/ml ketamine) on nondomestic zoo ruminants is discussed. Arousal time, recovery time and changes in the parameter of circulatory and respiratory functions after antagonization are shown. Tolazoline is able to antagonize the xylazine effect completely within a short time. Using a dosage of 3-5 mg/kg there is a marked negative effect on the cardio-vascular system. Yohimbine in the used dosage of 0.25-0.3 mg/kg in non-domestic ruminants did not approve in its effects. Combining yohimbine (0.25-0.3 mg) with 4-aminopyridine (0.5 mg/kg) recovery time is about 30 minutes. The negative effect on the cardio-vascular system is less pronounced compared with tolazoline.
讨论了拮抗剂妥拉唑啉、育亨宾以及育亨宾与4-氨基吡啶的组合对“黑尔布伦混合物”（125毫克/毫升甲苯噻嗪和100毫克/毫升氯胺酮）中甲苯噻嗪成分对非家养动物园反刍动物作用的逆转能力。展示了拮抗后觉醒时间、恢复时间以及循环和呼吸功能参数的变化。妥拉唑啉能够在短时间内完全拮抗甲苯噻嗪的作用。使用3 - 5毫克/千克的剂量对心血管系统有明显的负面影响。在非家养反刍动物中使用0.25 - 0.3毫克/千克剂量的育亨宾效果不佳。将育亨宾（0.25 - 0.3毫克）与4-氨基吡啶（0.5毫克/千克）联合使用时，恢复时间约为30分钟。与妥拉唑啉相比，对心血管系统的负面影响不那么明显。
