组胺H1受体拮抗剂对大鼠肝脏碳水化合物和脂质代谢调节的影响。
Effect of histamine H1-receptor antagonist on the regulation of carbohydrate and lipid metabolism in rat liver.
作者信息
Koyama Y, Imoto M, Tanaka M, Fukuda Y, Miyazawa Y, Nakano I, Ozawa T
机构信息
Department of Internal Medicine, Faculty of Medicine, University of Nagoya, Japan.
出版信息
Biochem Int. 1989 Feb;18(2):399-403.
In order to elucidate the role of histamine in the liver, we studied the effect of a histamine H1-receptor antagonist on the carbohydrate and lipid metabolism in the rat liver. The administration of the H1-receptor antagonist decreased significantly the contents of glycogen and malonyl-CoA in the liver. However, it did not affect the levels of serum glucose and free fatty acid. These results suggest that histamine may play a part in the regulation of metabolism of carbohydrates and lipids in the liver.
为了阐明组胺在肝脏中的作用，我们研究了组胺H1受体拮抗剂对大鼠肝脏碳水化合物和脂质代谢的影响。给予H1受体拮抗剂后，肝脏中糖原和丙二酰辅酶A的含量显著降低。然而，它并未影响血清葡萄糖和游离脂肪酸的水平。这些结果表明，组胺可能参与肝脏中碳水化合物和脂质代谢的调节。
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