在人类B细胞和胶质母细胞瘤细胞系中，组胺可增加白细胞介素-6的生物合成。
Interleukin-6 biosynthesis is increased by histamine in human B-cell and glioblastoma cell lines.
作者信息
Falus A
机构信息
Department of Molecular Biology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary.
出版信息
Immunology. 1993 Feb;78(2):193-6.
An enhancing effect of histamine on the biosynthesis and gene expression of interleukin-6 (IL-6) by human cell lines, Epstein-Barr virus (EBV)-infected human B lymphoma line BMNH and the glioblastoma line SK-MG4 has been found. No similar effect of histamine has been detected on the IL-6 production by any other B-cell line, CESS or human peripheral monocytes. Histamine stimulates the IgM production of BMNH cells by autocrine action of IL-6 induced by histamine, since either neutralization of IL-6 by polyclonal antibody or blocking the IL-6 receptor by specific monoclonal antibody abolished the effect of histamine.
已发现组胺对人细胞系、爱泼斯坦 - 巴尔病毒（EBV）感染的人B淋巴瘤系BMNH和成胶质细胞瘤系SK - MG4的白细胞介素 - 6（IL - 6）生物合成及基因表达具有增强作用。未检测到组胺对任何其他B细胞系CESS或人外周单核细胞的IL - 6产生有类似作用。组胺通过组胺诱导的IL - 6自分泌作用刺激BMNH细胞的IgM产生，因为用多克隆抗体中和IL - 6或用特异性单克隆抗体阻断IL - 6受体均可消除组胺的作用。
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