Halme A, Kellokumpu-Lehtinen P, Lehtonen T, Teppo L
Second Department of Surgery, University Central Hospital, Helsinki, Finland.
Br J Urol. 1989 Jul;64(1):78-83. doi: 10.1111/j.1464-410x.1989.tb05527.x.
The histology of 75 testicular germ cell tumours in 73 patients with treated or untreated cryptorchidism was investigated in a group of 503 patients with testicular germ cell tumour and evaluated according to the WHO classification. The proportion of pure seminoma was associated with the height of the testis, being 87% in abdominal. 78% in inguinal and 50% in normally positioned testes. In patients operated upon for cryptorchidism, the current site of the testis seemed to be a more important determinant of this proportion than the original site. The proportion of pure seminoma which developed in testes after successful orchiopexy was equal to that in normally-descended testes (50%) and lower (39%) if orchiopexy had been performed before the age of 16 years. Similarly, among non-seminomas, a higher proportion of tumours containing teratoma tissue was found in cryptorchidism was successfully treated in childhood. It was concluded that a successful orchiopexy in childhood decreases especially the risk of seminoma.
在一组503例睾丸生殖细胞肿瘤患者中，对73例患有已治疗或未治疗隐睾症的患者的75例睾丸生殖细胞肿瘤的组织学进行了研究，并根据世界卫生组织分类进行了评估。纯精原细胞瘤的比例与睾丸位置有关，位于腹部的睾丸中该比例为87%，腹股沟处为78%，正常位置的睾丸中为50%。在因隐睾症接受手术的患者中，睾丸当前位置似乎比原来位置更能决定这一比例。成功进行睾丸固定术后睾丸中发生的纯精原细胞瘤比例与正常下降睾丸中的比例相同（50%），如果在16岁之前进行睾丸固定术，该比例则更低（39%）。同样，在非精原细胞瘤中，隐睾症患者中含有畸胎瘤组织的肿瘤比例更高，若在儿童期成功治疗隐睾症则该比例更高。研究得出结论，儿童期成功进行睾丸固定术尤其能降低精原细胞瘤的风险。
